Excited to read this review on HSC inflammation and aging in Experimental Hematology from Mick Milsom and Jennifer Trowbridge in Experimental Hematology ISEH. exphem.org/article/S0301-…

A stellar presentation by Mick Milsom refining the models of HSC self-renewal, lineage skewing, competition, and exhaustion at Club CHO

Very excited that our paper on iPSC-derived bone marrow organoids is now out @NatureMethods twtr.to/0eBZd Thanks to the KleinLab Universität München @LMU_Uniklinikum and great collaborators carsten marr Helmholtz Munich | @HelmholtzMunich PenningerLab IMBA imbavienna.bsky.social Kotlarz Lab Enard/Hellmann Lab

Check out our study linking T cell signatures with allo-HCT outcome in AML patients out in @BloodJournal🩸 Big thanks to everyone involved, especially to dienstmüde ¯\_(ツ)_/¯ and my PhD supervisors Judith Zaugg @EMBL & C.Pabst Universitätsklinikum Heidelberg MMPU. 🧵(1/11) ashpublications.org/blood/article/…

Swing by for a taste of TFs, chromatin and single molecule footprinting!

"Tempora mutantur, et nos mutamur in illis". Ovid knew long ago that our somatic genomes evolve throughout life... Super excited to share our new paper on connecting clonal outgrowth in somatic evolution with epigenetic profiles nature Open here: rdcu.be/dHkeS 🪡

Fantastic talk yesterday at the New Investigator Award session of #ISEH2024 from my friend and colleague Charles Dussiau who presented his postdoc work in the Mick Milsom’s lab about aging of the hematopoietic system. Congrats!!🍾

Amazing talk from my labmate Ian Ghezzi who presented his PhD work at #ISEH2024 on the role of cancer stem cells in JAK2 mutated MPN at Experimental Hematology Lab. He completely rocked the stage!

Congratulations to our very own Marcel Rommel on winning the Pre-Meeting Workshop Best Poster Presentation award at this year’s ISEH conference. So very well-deserved! Bonus points for matching outfits with Camilla!

Had an incredible time at HI-STEM - Cancer and Stem Cells in Heidelberg! Truly impressed by the cutting-edge science and the interactive discussions with the team, including Mick Mick Milsom and Marieke. A huge thank you to Dr. Andreas Trumpp for hosting my seminar—excited to collaborate on HSC metabolism!!

Aging research enthusiasm alert 🚨 in our last review, we wanted to share some thoughts regarding the impact of time on the entire hematopoietic system - going beyond the usual focus on aged HSCs 🧫 check this out 🤩

Years of hard work finally put together 🚀So proud of the new collaborative piece from the Experimental Hematology Lab et al. crew ✨Huge shoutout to my friend Esther Rodriguez Correa, Florian Grünschläger and the rest of the team who led this 🥼🧪🐭

We were promised that in America we'd be able to pursue high-risk, ambitious science. We're not letting that dream go yet🇺🇸

New paper 🚨 : ‘The next big thing is small’ In latest article from Cheytan et al., Andreas Trumpp Group, published in @MolecularCancer, providing the first key insights into the role of organ-derived small extracellular vesicles and particles (sEVPs) in breast cancer metastasis.

Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to TF binding perturbations at the single molecule level bit.ly/3XQMFxN. I'm so grateful to my PhD mentors Arnaud Krebs and Judith Zaugg for these super productive years!!

And don't forget to checkout our annex pre-print bit.ly/3EkRqJh for a sense on our new 💻 tool FootprintCharter, for the unsupervised footprint quantification from single molecule data. Available on Bioconductor at bit.ly/3XLe8RC.

Excited to share our exploration Nature Methods into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with Omer Ali Bayraktar , Oliver Stegle and Moritz Mall groups. Preprint at end🧵👇

Dear NYC postdocs: the Postdoc Night Science is coming to our very own NY Genome Center on June 2, 5:30-7:30 pm! Let's dive into the art of asking the right questions, then network with fellow postdocs & find new science buddies 😊 Register below!

Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. biorxiv.org/content/10.110…