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Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases go.nature.com/3zPEIjp

I'm a little late to the party, but glad to share that our manuscript describing click editing has been published in Nature Biotechnology. An amazing team effort led by Joana Ferreira da Silva Connor Tou & others. CGM at MGH @MGH_RI Harvard Medical School #clickediting 🧬 nature.com/articles/s4158…

In a new Nature Biotechnology study, researchers from CGM at MGH and colleagues investigated programmable genome writing via click editing with DNA polymerases and HUH endonucleases. Read more: massgeneral.org/news/research-… Ben Kleinstiver Joana Ferreira da Silva Connor Tou

Really proud to see this work published -- a thrilling detective story I was lucky to be a part of. Big kudos to Stephen Tang and the entire team for an impressive collaborative effort. See Stephen's thread below to learn more... (and read the paper!). drive.google.com/file/d/1_paZuA…

Genome editing with DNA-dependent polymerases #NBTNV go.nature.com/3WUmCod

Was fun to tune in online with a mini watch party yesterday to catch Joana Ferreira da Silva's presentation on updated & engineered #clickeditors at the Cold Spring Harbor Laboratory #CRISPR talk (on behalf of a large collaborative effort in the lab). Excellent talk, Jo! 🧬👏 CGM at MGH @MGH_RI MassGeneral News

Check out our bioRxiv describing our efforts to treat a severe vascular disease 🫀: 1️⃣ Optimization of a target-specific base editor🧬 2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱 3⃣ Substantial extension of lifespan following in vivo base

Thrilled to see our work out in Nature Methods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.

🚨 Interested in precise, multi-kilobase scale insertions into the genome? Check out our detailed protocol describing PASTE, out in Nature Protocols ⬇️ nature.com/articles/s4159…

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! nature.com/articles/s4158…

Interested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥 We're hiring graduating seniors who are seeking ~2 years of post-bac research experience. If you're interested in gaining experience in next gen medicines, please reach

So excited to share our new paper out today in nature. We repurposed R2 retrotransposons to create STITCHR, a tool that can make diverse edits in mammalian genomes including scarless multi-kilobase scale insertions nature.com/articles/s4158…

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…