whoa, this is bigger than ChatGPT to me. google almost solved music generation, i'd say. google-research.github.io/seanet/musiclm…

Interested in epigenetics and the potential function of histone modifications? If so, Hua Wang in our lab has done some beautiful work in defining a role of H3K4me3!! Check out the paper - published today. nature.com/articles/s4158…

Nicole DelRosso's "Large-scale mapping and mutagenesis of human transcriptional effector domains" now out nature! >1,000 effectors and their sequence determinants discovered from screening >2,000 nuclear proteins nature.com/articles/s4158… From Bintu Lab in collab w Michael C Bassik

40 years of BIF in numbers. Great celebration near Frankfurt with 170 BIF fellows. The impact of BIF on education and support of young scientists is impressive. 👏 bifonds.de/index.html #education #science is our passion

Happy to share my postdoc work about enhancer-enhancer cooperativity! Find out more at biorxiv.org/content/10.110…

Interested in systems biology, gene expression, chromatin, genome structure, AI & deep learning? Please join us - Stirling Churchman, Sara Mostafavi, Alistair Boettiger and all amazing speakers) - on March 13-16 2024 at CSHL (NY, US): meetings.cshl.edu/meetings.aspx?… (please RT)

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in nature nature.com/articles/s4158…. Thread 👇(1/N)

Pinpointing causal variants that disrupt development. So proud of the amazing team on this epic enhancer genotype-to-phenotype study. Well Done, Fabian Lim, Joe Solvason, Genevieve Ryan, Sophia Le, Granton Jindal, Paige Steffen and Simran Jandu!!! doi.org/10.1038/s41586…

How many genes are in the human genome? (The third in an irregular series of threads about #Bioinformatics.) Let’s start by restricting “gene” to mean “protein-coding gene.” For the moment, this number appears to be just under 20,000, far lower than it used to be 1/11

Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju

Just earned my PhD! 👨‍🎓 Huge thanks to all who helped me reach this milestone.

🎉Congratulations to Filip Nemcko from Alexander Stark's lab for being included in Forbes Slovakia “30 Under 30” list! To earn him the mention is the development of a method that significantly speeds up the understanding of human gene functions. imp.ac.at/news/article/f…

How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s4158…

How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by Grace Bower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/

ORFtag enables protein functional screens by proteome-wide tagging via randomly integrated cassettes. Filip Nemcko Ulrich Elling @juliusbrennecke Alexander Stark StarkLab IMBA imbavienna.bsky.social IMP Max Perutz Labs Vienna Vienna BioCenter nature.com/articles/s4159…

Our latest research on position-dependent transcriptional regulatory sequences in plants is now published! 🌿 More details in our preprint tweet and in this thread! 👇 nature.com/articles/s4158… 📄🔍 (1/5)

Honored to receive the VBC PhD Award!