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New! Online now: Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin dlvr.it/TJphMr

#Hypertriglyceridaemia-induced acute #pancreatitis is a complex inflammatory disease that requires immediate medical attention and supportive care thelancet.com/journals/landi… #triglycerides

Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and #obesity Cell Research nature.com/articles/s4142…

GLP-1 discovery science started ~40 yrs ago in Boston & Copenhagen. The remarkable GLP-1 medicine story continues to unfold-featured this year April 2, 2 pm at the Warren Triennial Prize Symposium at MGH MassGeneral News Harvard Medical School #diabetes #Obesity massgeneral.link/warren2025

Big congrats to the Four Musketeers of GLP-1🤩🚀 Well-deserved recognition of their life-changing and impactful science👊🏼❤️

Here, Lirpa et al. establish GLP-3 as an accelerator of acetaldehyde metabolism and provide evidence of a gene-editing 'one-jab'n'done' therapy boosting GLP-3 expression and preventing hangovers from alcohol intoxication life-long! Open access: cdn.cdnparenting.com/articles/2022/…

Cold exposure reshapes the secretome of #BrownAdipocytes, spotlighting CXCL12 as a key #chemokine. CXCL12 boosts #thermogenesis and enhances communication with #macrophages and neurons revealing novel pathways for #metabolic adaptation. 👩‍🔬👨‍🔬UCPH Healthscience 🔗sciencedirect.com/science/articl…

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From Team Rorsman: “Islet α-cells are functionally heterogenous and their electrical excitability and glucagon release are determined by K+ channel activity due to variable mosaic of KATP and somatostatin-sensitive K+ channels reflecting metabolic state and proximity to δ-cells.”

Tough one…

Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise | Physiological Reviews | American Physiological Society journals.physiology.org/doi/abs/10.115…

The exerkine meteorin Metrnl is a potential therapeutic target for preserving human beta cell function and survival in type 1 #diabetes @diabetologiajnl link.springer.com/article/10.100…

Meet FGF21’s counter-hormone when it comes to regulation of protein intake: tachykinin from enteroendocrine cells is secreted in response to protein intake and reduces prefererence for protein🤗 It also seems to keep you awake when protein is available.

Here, treatment with a GLP-1R agonist effectively alleviated hyperphagia, body weight gain, improved glucose tolerance, and circulating metabolic hormones in BBS5-/- mice jci.org/articles/view/… Journal of Clinical Investigation

Towards individualized #precisionmedicine and prediction of risk and treatment responses #heartdisease UK Biobank Nature Medicine nature.com/articles/s4159…

Hematocrit for the glucose-lowering win-an increased mass of circulating erythrocytes is associated with reduced glycemia and with a lower prevalence of #diabetes mellitus in humans Science Advances science.org/doi/10.1126/sc…

Incredibly proud of this work. We detail the evolution of liver-secreted and plasma proteins with MASLD progression, providing a rich resource defining human hepatokines and a predictive model that stratifies MASH. William De Nardo UniMelb MDHS cell.com/cell-reports-m…

Digestion and absorption of nutrients 📍 📸: GI System at a Glance

Quick refresher on LFTs 💡

A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, resulting in alleviation of ER stress and reduction of beta-cell immunogenicity thereby protecting against #T1D #Genetics Cell cell.com/cell/fulltext/…