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Interesting analysis from I-SPY investigators. Although nonsignificant, the negative prognostic impact of cT 3/4 at diagnosis in HER2-positive patients achieving pCR is consistent with other studies. pubmed.ncbi.nlm.nih.gov/40551254/

This looks promising...for sure, worthy of a "slow reading". x.com/ASCOPost/statu…

A Multi-Institutional Analysis of Contralateral Axillary Metastases: Advanced Local-Regional Disease Divergent from Stage IV Breast Cancer - PubMed A nice paper on a clinical dilemma pubmed.ncbi.nlm.nih.gov/40394326/

Conoccurring mutations in GATA3 mut tumors may reveal actionable targets in HR+ resistant tumors. Genomic and proteomic profiling of GATA3 mutant metastatic hormone receptor-positive breast cancer and impact on clinical outcomes - PubMed pubmed.ncbi.nlm.nih.gov/40439821/

Exercise is medicine. Physically active breast cancer survivors had 31% (95% CI: 25–37%) reduction in risk of breast cancer mortality relative to physically inactive pts. pmc.ncbi.nlm.nih.gov/articles/PMC12…

🏃‍♀️🏋️🏋️‍♂️🎾👟Further evidence on the benefit of physical activity #exercise #strength training for chronic medical conditions from a RCT rdcu.be/evps3 Nature Medicine

In my opinion, this is the best reading of the year so far (at least for me). Worthy of a "Slow reading". KUDOS to the authors. nature.com/articles/s4159…

1/11 Our study on subclonal immune evasion in non-small cell lung cancer has just been published in Cancer Cell cell.com/cancer-cell/fu…

Endocrine therapy and risk of cardiovascular disease and mortality in postmenopausal breast.. academic.oup.com/jnci/article-a… The old issue of AIs being detrimental for cardiovascular health is rediscussed in this nice paper. AIs seem to reduce cardiovascular morbidity and mortality.

Breastfeeding After Hormone Receptor–Positive Breast Cancer: Results From the POSITIVE Trial | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC… Another valuable info from the POSITIVE trial

Breastfeeding after breast cancer in young BRCA carriers academic.oup.com/jnci/article/d… This one too, for BRCA carriers

Microenvironmental differences may account for the different outcomes of breast cancer in black vs white Americans? Need to give this a "slow reading". Most important, are these druggable? pubmed.ncbi.nlm.nih.gov/40675986/

This is interesting. By binding to NK1R, the P protein can affect several aspects of cancer hallmarks. This intriguing article suggests an anticaner role for NK1R inhibitors commonly used to treat severe nausea an vomiting due to chemotherapy. pubmed.ncbi.nlm.nih.gov/40658620/

A Life on the Line and $250K in Medical Debt Amid Insurer Denials medscape.com/viewarticle/li… medscape.com/viewarticle/li… The battle of bots…always saddened by this type stories☹️😔

🎥 Orgogliosi del nostro Paolo Tarantino! Un esempio concreto del talento che può emergere dalla Scuola di Specializzazione in Oncologia Medica Università degli Studi di Milano IEO Paolo Tarantino Impegno clinico, ricerca internazionale e formazione di eccellenza.