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Today we report in Nature Medicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance DevermanLab (1/13) drive.google.com/file/d/1DVpKrz…

🌠 We're thrilled to announce our latest @HypothesisFund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵

Thank you so much @hypothesisfund and Ellen Yeh for supporting us in this new venture!! We're excited to get started! 🦠🔬❄️

Computational discovery and experimental validation of mammalian gut colonization factors. Work led by our own amazing Menghan Liu in collaboration with Sohail Tavazoie lab at Rockefeller University. Columbia Biological Sciences Columbia Systems Biology Biochemistry & Molecular Biophysics cell.com/cell/fulltext/…

#CryoSPARC v4.7 is out! 🚀  Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more! Full changelog: cryosparc.com/updates #cryoEM

Our April issue is live! 🌧️🌷 nature.com/nmeth/volumes/… On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang St. Jude Research. Paper: nature.com/articles/s4159…

Excited to share our new paper out in nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

PTM-Mamba: a post-translational modification-aware protein language model, for protein modeling and design. nature.com/articles/s4159…

2025 Canada Gairdner Award Winners Announced gairdner.org/resource-hub/2… Congrats to BMB faculty member Iva Greenwald, and mentor of many BMB scientists Gary Struhl for this tremendous honor!

Exciting paper in Nature Methods that pushes the boundaries of MSI and spatially-resolved omics🥳TEMI reaches single-cell spatial resolution and enables the profiling of hundreds of lipids, metabolites, peptides, and N-glycans in complex tissue. Check out: rdcu.be/eiIWy

Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein go.nature.com/4itODM4

Important discovery by Sabrina Absalon and team!

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…

New online! Gating mechanism of the two-pore-domain potassium channel THIK1 bit.ly/435XgI6

You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !

Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs Biochemistry & Molecular Biophysics reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online Cell! sciencedirect.com/science/articl…

Online now! Structural basis of human uromodulin filament networks in uropathogen capture dlvr.it/TKdsLM

Neuroinflammation across neurological diseases Science Magazine science.org/doi/10.1126/sc…