Fitzpatrick Laboratory (@fitzpatricklab) 's Twitter Profile
Fitzpatrick Laboratory

@fitzpatricklab

Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.

ID: 1052118018

linkhttp://www.fitzpatrick-lab.org calendar_today01-01-2013 08:16:52

3,3K Tweet

3,3K Followers

4,4K Following

David R. Liu (@davidrliu) 's Twitter Profile Photo

Today we report in Nature Medicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance DevermanLab (1/13) drive.google.com/file/d/1DVpKrz…

Today we report in <a href="/NatureMedicine/">Nature Medicine</a> the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance <a href="/DevermanLab/">DevermanLab</a> (1/13)
drive.google.com/file/d/1DVpKrz…
Hypothesis Fund (@hypothesisfund) 's Twitter Profile Photo

🌠 We're thrilled to announce our latest @HypothesisFund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵

🌠 We're thrilled to announce our latest @HypothesisFund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵
Structura Biotechnology (@structurabio) 's Twitter Profile Photo

#CryoSPARC v4.7 is out! 🚀  Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more! Full changelog: cryosparc.com/updates #cryoEM

Nature Methods (@naturemethods) 's Twitter Profile Photo

Our April issue is live! 🌧️🌷 nature.com/nmeth/volumes/… On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang St. Jude Research. Paper: nature.com/articles/s4159…

Our April issue is live! 🌧️🌷
nature.com/nmeth/volumes/…

On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang  <a href="/StJudeResearch/">St. Jude Research</a>. 

Paper: nature.com/articles/s4159…
Yodai Takei (@yodai_takei) 's Twitter Profile Photo

Excited to share our new paper out in nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…

Sergio Cruz-León (@sergiocruzleon1) 's Twitter Profile Photo

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

Nature Methods (@naturemethods) 's Twitter Profile Photo

PTM-Mamba: a post-translational modification-aware protein language model, for protein modeling and design. nature.com/articles/s4159…

Biochemistry & Molecular Biophysics (@columbiabiochem) 's Twitter Profile Photo

2025 Canada Gairdner Award Winners Announced gairdner.org/resource-hub/2… Congrats to BMB faculty member Iva Greenwald, and mentor of many BMB scientists Gary Struhl for this tremendous honor!

Lingjun Li Research Group (@liresearch) 's Twitter Profile Photo

Exciting paper in Nature Methods that pushes the boundaries of MSI and spatially-resolved omics🥳TEMI reaches single-cell spatial resolution and enables the profiling of hundreds of lipids, metabolites, peptides, and N-glycans in complex tissue. Check out: rdcu.be/eiIWy

Exciting paper in <a href="/naturemethods/">Nature Methods</a> that pushes the boundaries of MSI and spatially-resolved omics🥳TEMI reaches single-cell spatial resolution and enables the profiling of hundreds of lipids, metabolites, peptides, and N-glycans in complex tissue. Check out: rdcu.be/eiIWy
nature (@nature) 's Twitter Profile Photo

Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein go.nature.com/4itODM4

ShorterLab (@shorterlab) 's Twitter Profile Photo

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…

Florent Waltz (@florentwaltz) 's Twitter Profile Photo

You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !

You want to start tomography? Solve structures inside cells? Reach Nyquist😳?
We have a website for you! tomoguide.github.io 
You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! 
Hope it will be useful !
Fitzpatrick Laboratory (@fitzpatricklab) 's Twitter Profile Photo

Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs Biochemistry & Molecular Biophysics reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online Cell! sciencedirect.com/science/articl…