
Fitzpatrick Laboratory
@fitzpatricklab
Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.
ID: 1052118018
http://www.fitzpatrick-lab.org 01-01-2013 08:16:52
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Today we report in Nature Medicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance DevermanLab (1/13) drive.google.com/file/d/1DVpKrz…




Computational discovery and experimental validation of mammalian gut colonization factors. Work led by our own amazing Menghan Liu in collaboration with Sohail Tavazoie lab at Rockefeller University. Columbia Biological Sciences Columbia Systems Biology Biochemistry & Molecular Biophysics cell.com/cell/fulltext/…


Our April issue is live! 🌧️🌷 nature.com/nmeth/volumes/… On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang St. Jude Research. Paper: nature.com/articles/s4159…



Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…



Exciting paper in Nature Methods that pushes the boundaries of MSI and spatially-resolved omics🥳TEMI reaches single-cell spatial resolution and enables the profiling of hundreds of lipids, metabolites, peptides, and N-glycans in complex tissue. Check out: rdcu.be/eiIWy



Important discovery by Sabrina Absalon and team!




Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs Biochemistry & Molecular Biophysics reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online Cell! sciencedirect.com/science/articl…


Neuroinflammation across neurological diseases Science Magazine science.org/doi/10.1126/sc…
