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Mortality in male bodybuilding athletes academic.oup.com/eurheartj/arti…

Disruption of cTnT-Mediated Sarcomere–Mitochondrial Communication Results in Dilated Cardiomyopathy ahajournals.org/doi/10.1161/CI…

The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy | JACC: Advances jacc.org/doi/10.1016/j.…

Metanalysis 📌 Early AF ablation (≤1-y of diagnosis) 📣 ass. w/ ⬇️ risk of recurrence especially in 👫 ≤55y #afib #EPeeps #CardioTwitter #Metanalysis Jason Andrade Andrea Natale MD Prash Sanders Prof Dhiraj Gupta Tom De Potter Diego Segura-Rodríguez Mamas A. Mamas Dr. José Ángel Cabrera

New JACC Journals #JACCHF   ⭐️Clinical profiles & occurrence of SCD by #HCM phenotype ⭐️Performance validation of current guidelines doi: 10.1016/j.jchf.2024.12.006.

#CONFIDENCE 1⃣ + 1⃣ = 2⃣ Remarkably, kidney protection with combination therapy mathematically identical to what would be expected based on each monotherapy Finerenone (0.68) * Empagliflozin (0.71) Combination (Expected if Fully Additive): 0.48 Combination (Observed): 0.48

ALPK3 Heterozygous Truncating Variants Cause Late-Onset Hypertrophic Cardiomyopathy With Frequent Apical Involvement and Apical Aneurysm | Circulation: Genomic and Precision Medicine ahajournals.org/doi/10.1161/CI…

#OriginalResearch: DSc-2mRNA treatment exhibits a therapeutic potential in the treatment of ARVC on animal models, establishing a foundation for prospective clinical applications. #AHAJournals Yan Zou Jennifer Wong Yuxiang Dai ahajrnls.org/44bwcYw

#HuelgaMedica13J

An argument for reduced dosing frequency of GLP-1s 💉 to maintain long-term weight loss ⚖️, based on mathematical modeling 📊: ➡️ Switching semaglutide from 1x/week to 1x/2 weeks = 50% fewer doses but 72% of weight loss retained ✅ ➡️ 1x/month may preserve ~50% of weight loss 🗓️

🆕 ACC Scientific Statement on managing #obesity in adults w/ #HF reviews Dx, evaluation, & risk assessment; outlines HF-specific Tx strategies including lifestyle changes, medications, & surgery; & highlights 🔑 evidence gaps & future directions jacc.org/doi/10.1016/j.… #JACC

Family Screening in Relatives at Risk for Plakophilin-2–Associated Arrhythmogenic Right Ventricular Cardiomyopathy ahajournals.org/doi/10.1161/CI…

From ignored to essential: #HeartFailure with improved EF isn’t a footnote anymore. This #JACC review charts a path from vague definitions to clinical clarity. jacc.org/doi/10.1016/j.… #HFimpEF #LVEF

📌Right heart catheterization in #HeartFailure: indications, interpretation, & pitfalls #CardioTwitter #CardioEd #RHC #HF #EHJ

🚨 Heart failure (HF) decongestion ≠ simple fluid removal. Let’s explore the fascinating electrolyte changes happening behind the scenes and how they interact with diuretic therapy. 🫀💧⚡ Here follows a thread.🧵 Full review by Frederik H. Verbrugge and me: onlinelibrary.wiley.com/doi/10.1002/ej…

The Relevance of the Type of Ventricular Arrhythmia in Titin-Related Dilated Cardiomyopathy: A Multicenter Study | JACC: Clinical Electrophysiology Small cohort of TTNtvs with high arrhythmic burden (PVCs) or SMVT. SMVT origin: septal predominance Complete abolition of PVCs

Universal application of CEP devices during TAVI do not appear to lead to measurable clinical benefit in an unselected population Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | New England Journal of Medicine nejm.org/doi/full/10.10…

Tailored therapeutics for cardiomyopathies nature.com/articles/s4156…

🧠 Tirzepatide doesn’t just reduce appetite—it rewires the brain. - - - A new Nature Medicine Phase 1 RCT (n=114) explored how tirzepatide changes eating behavior—and the brain’s response to food—in people with overweight or obesity. 📉 Key Findings at 3–6 Weeks 🔹-524 kcal/day