🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

My paper on #docking and #virtualscreening for #SARSCoV2 now highlighted on the Front Cover of ChemMedChem! CUDSanJavier @UPCTnoticias #compchem #falsetheoreticalfriends …mistry-europe.onlinelibrary.wiley.com/doi/full/10.10…

Wondering what’s new with drug development for repairing #myelin in #MultipleSclerosis and related disorders? Our new review will get you caught up. Hot off the press! nature.com/articles/s4158…

Happy to see this out in press now J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Very grateful to participate in this amazing work that uses a DEEP LEARNING model to discover highly synergistic drug combinations, with Jake P. Taylor-King, Mila - Institut québécois d'IA, Relation, and Scripps Research

A resurgence of allosteric inhibitors! Check out the Cravatt lab Scripps Research and Vividion Therapeutics selective, #covalent #allosteric JAK1 inhibitor rdcu.be/cVqZZ, and the recently approved allosteric TYK2 inhibitor! Bristol Myers Squibb bit.ly/3QvVWEP

I will be giving a talk @ an outstanding AACR Special Conference on Cancer Metastasis, chaired by FabriceAndre Sean Morrison, Danny Welch & Zena Werb with a spectacular set of speakers #AACRmet22. (Nov 14-17, Portland, Oregon), Additional information: bit.ly/3DIUZ9M

Undergraduates looking toward graduate school in the chemical & biological sciences can meet Scripps Research reps next week at the events listed below & at scripps.edu/gradschool. Meet us in-person at Virginia Tech, Penn, William & Mary or virtually at several others.

Huge congrats to Carolyn Bertozzi, Meldal, and Scripps Research colleague Sharpless! A rare 2nd The Nobel Prize for Barry and this makes it 2nd The Nobel Prize for Scripps Research in last 2 years!

Professor K. Barry Sharpless is only the fifth individual to have ever been awarded two lifetime Nobel Prizes. 2001 and 2022.

As I tell my kids, it takes alkynes to make a world. What a great time to be Scripps Research

Today we report in ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with Chris Parker and Luke Lairson the remarkable biological activity of this natural product family was revealed

A Scalable #TotalSynthesis of Portimine A & B by Junchen Tang, Weichao Li, Tzu-Yuan Chiu, Zengwei Luo, Christine Chong, Qijia Wei, Francisco Martinez-Pena, Nathalia Gazaniga, Yiyang See, Luke Lairson, Chris Parker, Baran Lab at Scripps Research in ChemRxiv chemrxiv.org/engage/chemrxi…

Fascinating talks by Chris Parker and Haoxin Li, from Scripps Research at #SLAS2023 today. They talked about difficult targets and expanding the ligandability of the proteome. The session was also hosted by Katya Vinogradova. Totally extraordinary and inspiring science!

Very excited to share our paper in J. Am. Chem. Soc. describing a prodrug that is selectively toxic to glioblastoma tumor cells. Huge thank you to Luke Lairson, Francisco Martinez-Pena, and our amazing collaborators Mischel Lab! Scripps Research pubs.acs.org/doi/10.1021/ja…

I’m very glad to share our work on Inorganic Chemistry: “Reversible Chromism of Tethered Ruthenium(II) Complexes in the Solid State”. A bunch of thanks to Sonia Infante-Tadeo, @pizarroam, and Jose S Costa from IMDEA Nanociencia 🔬. Thanks Scixel for the cover. pubs.acs.org/doi/10.1021/ac…

I am delighted to share our work demonstrating the active role of hydroxyproline and collagen metabolism in modulating PD-L1 expression &implications for cancer immunotherapy sciencedirect.com/science/articl…

The final version of this study was published today in nature : nature.com/articles/s4158…

Excited for this scripps Chem collaborative work out in nature w/Baran Lab & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more

#Synthesis of portimines reveals the basis of their anti-cancer activity by Junchen Tang, Weichao Li, Tzu-Yuan Chiu, Francisco Martinez-Pena, Zengwei Luo, Christine T. Chong, Qijia Wei, Nathalia Gazaniga, Thomas J. West, Yiyang See, Luke L. Lairson, Chris Parker, and Phil S. Baran

We are excited to share our latest paper Cell Press on RECOVER which was co-led by our CIO Jake Taylor-King Jake P. Taylor-King and Yoshua Bengio Mila - Institut québécois d'IA   #cause2cure #patientiswaiting lnkd.in/eQXacmWS