Now live in Nature Communications, dive into novel insights from our largest genome-wide association study (GWAS) and whole-exome gene burden analysis to date of Anterior Uveitis (AU), a major histocompatibility complex (MHC) class-1 disease defined by anterior eye inflammation.

Our TRGT paper published today in Nature Biotech! nature.com/articles/s4158… Tandem Repeat Genotyping Tool (TRGT) is a new method for genotyping tandem repeats in PacBio HiFi long reads. We used some nice algorithmic strategies to improve genotyping accuracy.

Excited to see this out! Congratulations to Kairavi and Andrea! University of Toronto U of T Mississauga U of T Anthropology U of T Public Health

Study links clinical diagnoses and laboratory tests to PTSD polygenic risk across four health care systems, revealing shared genetic architecture of PTSD and physical health. ja.ma/3viMRu9 Yale Psychiatry @GitaPathakPhD Kritika Singh Renato Polimanti

What if we could inducibly create thousands of structural variants and ecDNAs in human cells and see which ones survive? biorxiv.org/content/10.110… I’m excited to share our story on scrambling the human genome by combining prime editing, repetitive elements, and recombinases. A🧵

Another new study led by Brenda Cabrera Mendoza is on Nature Human Behaviour! Using PGC Consortium, VA Research, and UK Biobank, we assessed assortative mating, participation bias, and SES effect on behavioral PRS. Big thanks to Loïc Yengo for working with us on this! nature.com/articles/s4156…

New preprint from my former team University of Toronto U of T Anthropology U of T Public Health. We identified and characterized repetitive elements associated with hair color variation. Great work Mary Anne Panoyan Cristina Ashley and Victoria!

(4/5)💡Can anxiety comorbidity be used to overcome missing data? Frank Wendt et al used comorbid phenotype patterns to increase GWAS power by imputing #GAD symptoms in those not assessed in the UK Biobank #mentalhealth questionnaire nature.com/articles/s4138…

I have an opening for a PhD student for the Fall 2024 (details regarding stipend and program below). I will be at the APS summit next week and am available to discuss. Project will be primarily related to remote ischemic preconditioning using human and cell models. Please share!

Now published! We investigated the comorbid phenome of PTSD vulnerability and resilience doi.org/10.1016/j.psyc… (open access🔓) @PsychiatryResearch @medofak_uib Yale Psychiatry A thread 🧵 1/11

STRchive (strchive.org), an online database of tandem repeat disease loci in humans. Hiatt et al. medRxiv medrxiv.org/content/10.110…

💡Daskalakis & Ressler labs McLean Hospital Harvard Medical School are extremely excited & proud 🥳to share that our collaborative work with Nemeroff UT Austin and Kleinman Lieber Institute labs on molecular underpinnings of #PTSD & #MDD is out Science Magazine science.org/doi/10.1126/sc…! 🧵👇

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program is now online Science Magazine. science.org/doi/10.1126/sc…

In this newly published paper we took another step along the road to a developmentally informed expansion of HiTOP We used very big samples and very broad assessment to map a symptom-level model of the structure of psychopathology in youth! journals.sagepub.com/doi/10.1177/21… 1/🧵

Everyone should apply to work with Gita!

More information on the Yale Psychiatry postdoctoral position can be found here:

In recent work led by chairs and members of the PGC SUI workgroup, the authors provide standardized definitions for suicidality phenotypes—ideation, attempt, death—to improve data consistency across studies. medrxiv.org/content/10.110…

New preprint examining associations between impulsive personality trait, alcohol consumption, and alcohol use disorder polygenic scores (PGSs) and binge drinking trajectories from adolescence into early adulthood in three independent longitudinal samples. medrxiv.org/content/10.110…

Get ready for an exciting lineup of presentations from team RGC. Catch us today through Friday as our speakers share cutting-edge research on topics from migraine and rare disease variants to height prediction and more. Don't miss the chance to learn and collaborate! #ASHG24

Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) Regeneron Genetics Center for meta-analysis of gene-based tests using summary statistics rgcgithub.github.io/remeta/ This is great work from Tyler Joseph. Pre-print is here​ medrxiv.org/content/10.110…