If you are at #hupo2024 in Dresden, do catch up with our lab-mates to know more about some of our exciting research in Matthias Mann Lab 👇

It was a great honor to speak at #HUPO2024 Human Proteome. Thanks to @IonOpticks for highlighting my presentation.

Did my Twitter handle break speech-to-text algorithms? 😂 @neely615 @ProteomicsNews

The Dawn of Spatial Medicine Until now, spatial omics was used to understand human biology. That changed when it saved lives of patients with a fatal skin condition. In the new Ground Truths, pioneering work by Matthias Mann Lab Thierry Nordmann Max Planck Institute of Biochemistry (MPIB) and an international

AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial Florian Rosenberger #Alpha1Awareness bit.ly/4hzl64o

The 68th Benzon Symposium report is now online in Molecular & Cellular Proteomics ! Fantastic conference that brought together top global experts in Copenhagen to translate proteomics to the clinics - from technological advances to regulatory frameworks! Matthias Mann Lab bit.ly/3AsuN3X

The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. nature.com/articles/s4159…

Exciting news - Spatial Proteomics is Nature Methods’ 2024 Method of the Year! Our commentary highlights how Deep Visual Proteomics (DVP) unites imaging, data science & high-res proteomics at single-cell resolution, fueling predictive tissue models and personalized medicine. Stay

Thrilled to see spatial proteomics as @NatureMethods Method of the Year 2024! As pioneers of Deep Visual Proteomics (DVP), we're excited to help map the spatial proteome at unprecedented depth #MethodOfTheYear #SpatialProteomics #DeepVisualProteomics

Thrilled to share that our Zorya paper is now published online in Nature! It was an incredible team effort Philipp Popp Marc Erhardt SimonJackson —thank you to everyone who contributed to this work.Inga Songailiene Victor Klein-Sousa Aritz Roa Freddie Martin Yong Wang Alexander Harms ₳źiż

Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in Molecular Cell doi.org/10.1016/j.molc…

Proud to share our work on mipDVP, now online in Molecular Cell! It’s been an incredible journey working with a fantastic team to uncover new insights into tumor microenvironments. CPRatUCPH Novo Nordisk Foundation Matthias Mann Lab Miltenyi Biotec Thermo Fisher Bruker Leica Microsystems

Deep visual proteomics, a spatial omics technique that has already been shown to save lives, here applied to unraveling the crosstalk between immune cells and proteins in cancer tissue cell.com/molecular-cell… Molecular Cell Matthias Mann Lab Andreas Mund

Online Now: Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics dlvr.it/THM62z

News from the Matthias Mann Lab in Molecular Cell: Multiplexed imaging-powered Deep Visual Proteomics offers deeper insights into the tumor microenvironment by mapping 21 cell populations and quantifying thousands of proteins in each, revealing critical tumor-immune interactions. Huge

Our npj Journals npj Precision Oncology paper reveals how Deep Visual Proteomics maps protein networks across multiple organs in Signet Ring Cell Carcinoma, offering new perspectives on tumor evolution - one patient, four organs, many insights! rdcu.be/d8KyK

Thrilled to share our latest work published in Nature Genetics today: Plasma proteome variation and its genetic determinants in children and adolescents. 🩸#PediatricProteomics #PlasmaProteomics #pQTL nature.com/articles/s4158… 🧵A thread by Lili Niu explains below ⬇️

Our paper is out in nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. nature.com/articles/s4158…

Our paper on ovarian cancer #LGSC is out in Cancer Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…