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The Bias-Variance Trade-Off & "DOUBLE DESCENT" 🧵 Remember the bias-variance trade-off? It says that models perform well for an "intermediate level of flexibility". You've seen the picture of the U-shape test error curve. We try to hit the "sweet spot" of flexibility. 1/🧵

Edouard L. Fu, one of the Top 5 reviewers of 2024, finds that “Reviewing for JASN allows me to see the latest and greatest in nephrology first-hand. At the same time, it is incredibly exciting to help authors improve their manuscript and thereby elevate the quality of research in

Congratulations to top reviewer and past JASN editorial fellow Edouard L. Fu.

FINEARTS-HF Benefits of finerenone irrespective of concomitant use of an SGLT2i. Combined use of SGLT2i and a non-steroidal MRA may provide additive protection in HF with mildly reduced or preserved ejection fraction. Muthu Vaduganathan et al ahajournals.org/doi/10.1161/CI…

Yuzhi Xi American Academy of Pediatrics Derek K Ng Megan Carroll Sue Furth Brad Warady 𝐉𝐨𝐬𝐞𝐩𝐡 𝐅𝐥𝐲𝐧𝐧, 𝐌𝐃 CKiD Study Silvio Borrelli Paolo Chiodini Luca De Nicola Mark Canney Arenn Jauhal Heather Reich Sean Barbour Gian Luca Di Tanna A/Prof Clare Arnott Amy Kang Rajiv Agarwal MD, MS george bakris Seung Hyeok Han From the #Cardiorenal Collection: Cardiorenal Outcomes Among Patients With Atrial Fibrillation Treated With Oral Anticoagulants bit.ly/3V4G3c6 #OpenAccess @MarcoTrevi6 Catherine Clase 😷🌈🦋 Edouard L. Fu Juan Jesus Carrero #VisualAbstract

Our paper on applying missingness DAGs to longitudinal trial data has just been published in Biostatistics: academic.oup.com/biostatistics/… A challenging but rewarding experience. We give ideas on useful rules of thumbs & how to explore deviations from the assumed missingness process.

Our new textbook Theoretical Foundations of Conformal Prediction is out! Conformal prediction is a a statistical technique that augments ML systems with uncertainty information for safe deployment. This book lays out the core theory. arxiv.org/abs/2411.11824

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3ZdrYxb #OpenAccess Emilie Julie Lambourg Edouard L. Fu @C_H_Grant John Petrie Samira Bell #VisualAbstract #CKD

I am happy to announce that the first draft of my RL tutorial is now available. arxiv.org/abs/2412.05265

👉New paper with guidance for performance evaluation of predictive AI models. With The STRATOS initiative Ewout Steyerberg Maarten van Smeden Laure Wynants @laurewynants.bsky.social Gary Collins Andrew Vickers Gael Varoquaux 🦋 Karandeep Singh Lasai Barreñada Carl Moons Tina Hernandez-Boussard David McLernon arxiv.org/abs/2412.10288

Stopping Renin-Angiotensin System Inhibitors (RASi) in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study ca. 2021 from JASN_News Edouard L. Fu #Nephpearls #Cardiorenal #NephJC 👉 pubmed.ncbi.nlm.nih.gov/33372009/

Here are the first five sets of slides: 01 Introduction: psantanna.com/DiD/01_Introdu… 02 Classical 2x2 setup: psantanna.com/DiD/02_two_by_… 03 Clustering issues: psantanna.com/DiD/03_Cluster… 04 Functional form: psantanna.com/DiD/04_Functio… 05 Covariates: psantanna.com/DiD/05_Covaria…

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3CFBHmW #OpenAccess Emilie Julie Lambourg Edouard L. Fu @C_H_Grant John Petrie Samira Bell #VisualAbstract #CKD

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3CFBHmW #OpenAccess Emilie Julie Lambourg Edouard L. Fu @C_H_Grant John Petrie Samira Bell #VisualAbstract #CKD

Causal inference in observational studies can be tricky. We discuss key methodological considerations from a recent study in JASN ASN Publications. With Edouard L. Fu and Juan Jesus Carrero. Read it here: tinyurl.com/rwzu37xu

🔥 #CONFIDENCE closed out & selected as LBCT to headline #ERA25, led by #ProfRajivAgarwal Largest RCT to test combination #SGLT2i empagliflozin & #nsMRA finerenone Will 1+1 = 2? Baseline: academic.oup.com/ndt/advance-ar… Design: academic.oup.com/ndt/article/38… See you in Vienna 🇦🇹 ERA - European Renal Association

*30 years* after the start of the RALES trial the targeting of the MR axis remains one of the hottest areas of drug development across cardio-kidney-metabolism Expected read-outs in '25: #ACHIEVE sMRA in ESKD #CONFIDENCE Combo nsMRA+SGLT2i in CKD #SPIRITHF sMRA in HFmrEF/HFpEF

#GDMT has now arrived for #HFpEF #SGLT2i (class I) and #nsMRA (class IIa) recommendations in initial global guidelines jstage.jst.go.jp/article/circj/… #HeartFailure2025