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The peripheral membrane protein p47phox translocates a cytosolic activating complex to the membrane through its PX domain as part of NOX2 activation. Develin and Fuglestad Lab VCU show IP6 can break the lipid binding of PX, suggesting a regulatory role. pubs.acs.org/doi/10.1021/ac…

We are happy to share our most recent work! “Ligandability at the Membrane Interface of GPx4 Revealed through a Reverse Micelle Fragment Screening Platform” | JACS Au pubs.acs.org/doi/10.1021/ja…

Awesome flash talk by Sara at Protein Society this morning! Come check out her poster tonight - poster 29! #PS38

Check out our most recent publication! An NMR Approach for Investigating Membrane Protein–Lipid Interactions Using Native Reverse Micelles bio-protocol.org/en/bpdetail?id…

An NMR Approach for Investigating Membrane Protein–Lipid Interactions Using Native Reverse Micelles: bio-protocol.org/en/bpdetail?id… #lifesciences #research #biophysics

Officially sending off our graduates! Congratulations Courtney, Angela, and Abdul! 🎉🥂🍾

Fragments screened in reverse micelles: Fuglestad Lab finds fragment hits against the difficult enzyme GPx4 by surrounding it with a mimicked membrane (mmRM)  ACS Publications practicalfragments.blogspot.com/2024/08/fragme…

Big thanks to VCU Chemistry for hosting this year’s Graduate Poster session! We had a great time and some awesome conversations!

Congratulations to Dr. Fuglestad for being named a Patriotic Employer from the Office of the Secretary of Defense Employer Support of the Guard and Reserve!! 🇺🇸

Ligandability at the Membrane Interface of GPx4 Revealed through a Reverse Micelle Fragment Screening Platform By Courtney L. Labrecque & Fuglestad Lab Read the paper 👉 go.acs.org/aYE

Thank you to #SERMACS2024 for allowing Sara to present her research titled “Elucidating the membrane lipid interactions with GPx4”!!

Want to learn more about reverse micelles and using them to investigate membrane proteins?? Check out our new review! portlandpress.com/biochemsoctran…

Meet Kelly! Kelly is a 1st year Chemistry PhD student who joined our lab this semester! She is beginning work on exploring DNA and protein binding! Kelly graduated from VCU undergrad in three years and her favorite place is the beach! Welcome to the lab!

Meet Mackenzie! Mackenzie is a 1st year Chemical Biology PhD student who is joining our lab to further our fragment based drug discovery initiative! In her free time, she loves to play golf and pickleball and watch New Girl!

As the semester wraps up, we just wanted to share our most recent group photo! Happy Holidays!

Big news!! Dr. Fuglestad was recently awarded the 2024 Young Investigator Award from Eli Lilly and Company!!

Check out our new paper investigating biologically inspired reverse micelles for protein membrane interaction! Congrats to Rachel and Allyson for their first publication in the group!! pubs.rsc.org/en/content/art…

Congratulations to our lab’s two newest PhD candidates, Rachel and Jake! They both recently passed their candidacy proposals and we are excited to see them continue pursuing their research!!

Check out our latest publication! Congrats Aaron, Abdul, and George!! Broad PFAS Binding with Fatty Acid Binding Protein 4 Is Enabled by Variable Binding Modes | JACS Au pubs.acs.org/doi/full/10.10…

Congratulations to Sara for being a Graduate Best Poster Winner at PS39! 🎉🎉 Congrats to all the winners and thanks to the Protein Society for a great conference!!