Pauline Funchain (@funchainmd) 's Twitter Profile
Pauline Funchain

@funchainmd

Melanoma and cutaneous medical oncology. Studying hereditary and somatic genomics. LA explant in SF via OH. Sports fan, geek, and mommy. @funchainmd.bsky.social

ID: 766566714909876224

calendar_today19-08-2016 09:25:21

7,7K Tweet

2,2K Followers

1,1K Following

Shaalan Beg MD MBA FASCO (@shaalanbeg) 's Twitter Profile Photo

🥁🥁Introducing🥁🥁 *** #ASCO25 BINGO!! ** FRIDAY ROUND UP! Click here to claim your bingo card! 👇🏽 👇🏽 bingodoc.emergent.host #OnlyOncologistsInTheBuilding W/Emil Lou, MD, PhD, FACP Shruti Patel, MD, and thanks to Ankit kansagra for building the prototype for this app!

🥁🥁Introducing🥁🥁

*** #ASCO25 BINGO!! **

 FRIDAY ROUND UP!

Click here to claim your bingo card!

👇🏽  👇🏽

bingodoc.emergent.host

#OnlyOncologistsInTheBuilding 

W/<a href="/cancerassassin1/">Emil Lou, MD, PhD, FACP</a>
<a href="/ShrutiPatelMD/">Shruti Patel, MD</a>, and thanks to <a href="/kansagraMD/">Ankit kansagra</a> for building the prototype for this app!
ASCO (@asco) 's Twitter Profile Photo

2nd Plenary #ASCO25: #NIVOPOSTOP Ph III, adj Nivolumab w/ ChemoXRT in high risk squamous cell head & neck ca after surgery. - 3yr DFS: 63.1% vs 52.5% (HR: 0.76). Benefit in all subgroups including CPS/PDL1 - Similar AEs in both arms - Is benefit driven by locations control?

2nd Plenary #ASCO25: #NIVOPOSTOP Ph III, adj Nivolumab w/ ChemoXRT in high risk squamous cell head &amp; neck ca after surgery. 

- 3yr DFS: 63.1% vs 52.5% (HR: 0.76). Benefit in all subgroups including CPS/PDL1 
- Similar AEs in both arms 
- Is benefit driven by locations control?
Suneel Kamath MD (@skamath_md) 's Twitter Profile Photo

ATOMIC trial shows adjuvant atezolizumab + FOLFOX significantly improves DFS (86.4% vs. 76.6%) vs. FOLFOX alone. This is what federal #Cancer research can do. #ASCO25 #CancerTreatment

ATOMIC trial shows adjuvant atezolizumab + FOLFOX significantly improves DFS (86.4% vs. 76.6%) vs. FOLFOX alone. 

This is what federal #Cancer research can do.
#ASCO25 #CancerTreatment
Cristiane D Bergerot (@crisbergerot) 's Twitter Profile Photo

#ASCO25 education session on the evolving melanoma treatment landscape 🧬✨ Learn how to navigate care when immunotherapy is contraindicated and identify resistance to immune checkpoint inhibitors early—crucial insights across disease settings! Pauline Funchain Evan Lipson

#ASCO25 education session on the evolving melanoma treatment landscape 🧬✨ 
Learn how to navigate care when immunotherapy is contraindicated and identify resistance to immune checkpoint inhibitors early—crucial insights across disease settings! <a href="/FunchainMD/">Pauline Funchain</a> <a href="/evanlipson/">Evan Lipson</a>
ASCO (@asco) 's Twitter Profile Photo

5th Plenary #ASCO25: #MATTERHORN Ph III, Durvalumab + FLOT—>✂️—>Durva vs NeoAdj FLOT in resectable GEJ/Gastric Ca. - 2yr EFS 67% vs 59% (HR: 0.71). Improvement regardless of PDL1 - 2yr OS 76% vs 70%. mOS NR - Rate of✂️& number of FLOT similar in both arms - D-FLOT new SoC!

5th Plenary #ASCO25: #MATTERHORN Ph III, Durvalumab + FLOT—&gt;✂️—&gt;Durva vs NeoAdj FLOT in resectable GEJ/Gastric Ca.

- 2yr EFS 67% vs 59% (HR: 0.71). Improvement regardless of PDL1
- 2yr OS 76% vs 70%. mOS NR
- Rate of✂️&amp; number of FLOT similar in both arms
- D-FLOT new SoC!
Nikita Reddy Chintapally (@nktrddy) 's Twitter Profile Photo

MATTERHORN: Perioperative Durvalumab + FLOT vs FLOT alone in resectable G/GEJ adenoca + Taylor Swift quote 🤩 What an awesome way to end the day!! Yelena Y. Janjigian MD #ASCO #ASCO25

MATTERHORN: Perioperative Durvalumab + FLOT vs FLOT alone in resectable G/GEJ adenoca 

+ 

Taylor Swift quote 🤩

What an awesome way to end the day!!

<a href="/YJanjigianMD/">Yelena Y. Janjigian MD</a>
#ASCO 
#ASCO25
Shruti Patel, MD (@shrutipatelmd) 's Twitter Profile Photo

“Not everything that counts can be counted. Not everything that can be counted, counts.” -Mark Lewis, MD, FASCO In oncology, metrics matter. But meaning or time or values? You can’t quantify those. That’s why shared decision-making isn’t just a buzzword; it’s the ENTIRE point. #ASCO25

Nicholas Hornstein (@gimedonc) 's Twitter Profile Photo

If this were a pill, we’d call it revolutionary. It would headline plenaries, get FDA priority review, and cost $10,000 a month. Instead—it’s structured exercise. 🆕 NEJM June 2025 | CHALLENGE Trial Stage II–III colon cancer patients post-chemo (n=889) 📦 RCT of 3 years of

If this were a pill, we’d call it revolutionary.
It would headline plenaries, get FDA priority review, and cost $10,000 a month.

Instead—it’s structured exercise.

🆕 NEJM June 2025 | CHALLENGE Trial
Stage II–III colon cancer patients post-chemo (n=889)
📦 RCT of 3 years of
Pauline Funchain (@funchainmd) 's Twitter Profile Photo

Alright y’all - last day of #irAE content at #ASCO25 ASPIRE Community of Practice Monday 6/2 11:30a Bi/Multi-specific Antibodies S406 ➡️Giuseppe Curigliano ➡️Enriquita Felip ➡️Funda Meric Bernstam 3p Beyond Checkpoint E450b ➡️me 😇 ➡️Evan Lipson ➡️Jason Luke, MD, FACP

Charles Jiang MD, MPH (@charlesjiangmd) 's Twitter Profile Photo

So you've heard the practice changing exercise CHALLENGE trial! But what did that groundbreaking exercise program actually look like day-to-day? Let's explore the "Structured Exercise Program" based on info from their paper supplement on NEJM #ASCO2025 #ASCO25 1/10

Pauline Funchain (@funchainmd) 's Twitter Profile Photo

Acral melanoma pearls -adjuvant therapy not effective -targeted therapy with responses (not enough data to clearly choose IO vs targeted as 1L imho) -alternative regimens with efficacy in Asia (different biology than US?) Keri Kendra The Ohio State University College of Medicine #ASCO25 #rarecancers

Acral melanoma pearls
-adjuvant therapy not effective
-targeted therapy with responses (not enough data to clearly choose IO vs targeted as 1L imho)
-alternative regimens with efficacy in Asia (different biology than US?)
Keri Kendra <a href="/OhioStateMed/">The Ohio State University College of Medicine</a> 
#ASCO25 #rarecancers
Pauline Funchain (@funchainmd) 's Twitter Profile Photo

🌉“don’t burn bridges” ➡️ Swiftly moving from no options to what to do in what order with so many options - Marlana Orloff, Thomas Jefferson on metastatic uveal melanoma sequencing strategies #ASCO25 #rarecancers #RareDisease

🌉“don’t burn bridges” ➡️ Swiftly moving from no options to what to do in what order with so many options - Marlana Orloff, Thomas Jefferson on metastatic uveal melanoma sequencing strategies #ASCO25 #rarecancers #RareDisease
Allison Betof Warner, MD, PhD (@drbetofmdphd) 's Twitter Profile Photo

Powerhouse education session on Rare Melanomas at #ASCO25 covering desmoplastic, acral, uveal, and mucosal by Drs. Kendra, Orloff, and Guo - THE experts in the field. Follow Pauline Funchain for the play by play!

Pauline Funchain (@funchainmd) 's Twitter Profile Photo

Metastatic mucosal melanoma today: -combination immunotherapy shows lackluster efficacy -MEKi with 25% ORR -KIT + anti PD1 with 54.8% ORR -triplet ICI with 33% ORR -lenv pembro with 50% ORR -TIL with 50% ORR Jun Guo, Beijing Cancer #ASCO25 #raremelanoma #rarecancers #RareDisease

Metastatic mucosal melanoma today:
-combination immunotherapy shows lackluster efficacy
-MEKi with 25% ORR
-KIT + anti PD1 with 54.8% ORR
-triplet ICI with 33% ORR
-lenv pembro with 50% ORR
-TIL with 50% ORR
Jun Guo, Beijing Cancer
#ASCO25 #raremelanoma #rarecancers #RareDisease
Allison Betof Warner, MD, PhD (@drbetofmdphd) 's Twitter Profile Photo

I’ve been in the exercise oncology field for 20 years and for all of that time, the main criticism has been “show me a well controlled RCT.” Well, here it is. Exercise following adjuvant chemotherapy for colon cancer reduced recurrence and improves OVERALL SURVIVAL! #ASCO25

Annie Wong 黃毅敏 (@anmwongnz) 's Twitter Profile Photo

Wondering what’s involved in structured exercise? Behavioural coaching & hitting 10 MET (metabolic equivalent task) hours per week So that’s like 30min brisk walking 3 times/week 👟 Our standard of providing health info📄 not enough:time to FUND these support programs #ASCO25

Wondering what’s involved in structured exercise?

Behavioural coaching &amp; hitting 10 MET (metabolic equivalent task) hours per week

So that’s like 30min brisk walking 3 times/week 👟

Our standard of providing health info📄 not enough:time to FUND these support programs

#ASCO25