New Research: Optogenetic manipulation of cardiac repolarization gradients using sub-threshold illumination #Physiology frontiersin.org/articles/10.33…

Happy to share that our latest study is published in Frontiers in Physiology! We show that gradients in ventricular conduction and repolarisation can be manipulated by sub-threshold optogenetic stimulation. You can access the paper at: doi.org/10.3389/fphys.… @LeonardoSacconi

Enjoying the European Society of Cardiology #EWGCCE meeting in Copenhagen - great science and great people! #basicEP Molly O'Reilly Dan Johnson Simona Casini David Greensmith @LSkientist @chrisRJO Gerard Marchal

Our review published in this week's issue of #CardiovascularResearch The interplay of microtubule plus end binding proteins and #sodiumchannel interacting proteins mediates NaV1.5 delivery at subcellular domains summary ⬇️by Gerard Marchal CVR Tomasz Guzik academic.oup.com/cardiovascres/…

Also check out our previous work demonstrating the relevance of the microtubule plus end binding proteins EB1/MAPRE1 and EB2/MAPRE2 for #cardiac #sodiumchannel Nav1.5 function #SCN5A and #Brugadasyndrome ahajournals.org/doi/full/10.11… and nature.com/articles/s4158… Gerard Marchal

Hello all! Via this account, you can stay up to date on the developments of the Marie Skłodowska-Curie Actions postdoctoral fellowship of Gerard Marchal. The aim of this project will be the development of a panoramic cardiac optical mapping and manipulation platform.

Since the start of this project, we have been exploring the use of optogenetics to modify cardiac electrical dynamics. Recently, we demonstrated the possibility to locally manipulate conduction and repolarisation using patterned sub-threshold illumination: doi.org/10.3389/fphys.…

Our next steps will be to develop a panoramic optical manipulation-and-detection platform and explore pharmacological strategies to further enhance gradients in repolarisation. Future updates will be shared here!

Happy to share our latest publication! We provide a short review on the current state of cardiac optogenetics and introduce a new strategy for dual optical mapping, while also implementing optogenetics 👇

From render to reality🫀 We're making great progress with our optical platform and are currently optimising before the main experiments. This is a little sneak peek at our poster at the EWGCCE in Graz on 1-3 July, see you there!

The final paper from my PhD is out. 🍾 The end of an era! It's about the impact of genetic background on cardiac disease caused by sodium channel dysfunction. Check it out here: academic.oup.com/europace/artic… Thanks to all co-authors, and especially my PhD supervisor Carol Ann Remme