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We enjoyed chatting with Giuseppe Leuzzi and Alberto Ciccia about their collaborative work with EpiCypher - now in press at Cell! Check out our latest blog to dive into their work on how the chromatin protein SMARCAL1 impacts immune responses in cancer! hubs.la/Q02kH2wm0

I’m sorry to share the sad news that Michael Grunstein, Distinguished Prof UCLA Biological Chemistry David Geffen School of Medicine at UCLA UCLA passed away early this morning after 20 yr battle with Parkinson’s disease. Condolences to friends & family 💐 This is my note to the department.

Full text now out! Fantastic collaboration with EpiCypher, Inc. showing that nucleosome context matters for histone PTM readout, and that patterns of PTMs function both through direct readout and through conformational regulation eLife - the journal Department of Biochemistry and Molecular Genetics Department of Biochemistry and Molecular Biology doi.org/10.7554/eLife.…

"A true mentor is someone who has more imagination about you than you have about yourself" nejm.org/doi/10.1056/NE…

Product of a collaborative project with the newly minted Dr. Chad Hicks PhD (huge congratulations to same !) : H2BK120 controls access to a hub of nucleosome engagement : the acidic patch. Cynthia Wolberger Chad Hicks EpiCypher, Inc. #nucleosome biorxiv.org/content/10.110…

What is the state of possible for extracting open chromatin data from banked clinical samples - specifically FFPE patient tissues ? We've been thinking about it (helps when you're planning to do it) : our field review. EpiCypher, Inc. New England Biolabs #chromatin preprints.org/manuscript/202…

I was deeply honored to be recognized during the Florida Gators Men’s Basketball game tonight! Achieving UF Health Cancer Center designation from National Cancer Institute was a team effort involving the tremendous efforts of researchers and staff across FLORIDA and the support of our community, state & federal partners.

Some of what we've been up to for the past while ...

“If you want to know someone, look at their friends…” that’s how we decode histone codes and chromatin states. Finally, the dream has come true… Almost a decade after I started the project in London, it has been published on Nature. Enjoy the paper: nature.com/articles/s4158…

Publication alert ! Paper from helmholtz-munich.de/en/ife in nature How complex epigenetic modification signatures regulate genome function. With interactive online resource marcs.helmholtz-munich.de Big data ! Epigenetics Research at Helmholtz Munich Helmholtz Munich | @HelmholtzMunich nature.com/articles/s4158…

A lot of fun to highlight great work from Giuseppe Leuzzi and Alberto Ciccia et al showing how the the DNA translocase SMARCAL1 dampens immune responses against tumor cells through two distinct mechanisms. Together with Eleonore Toufektchan in Molecular Cell. authors.elsevier.com/a/1ijJ1_Oylrla…

Another great day at EpiCypher! We hosted Neil Kelleher - who described how mass spectrometry methods are transforming the study of nucleosome modifications and the histone code. Great to see you, Neil!

Behold : the coin-on-side stability of the Shanghai to Beijing bullet train [and at 347kph / 215mph] !

They have a beautiful campus at Seoul National University - as I found out when I gave the wrong address to Taxi driver - a very pleasant 30min walk ensued to visit Sung Hee Baek ! #asiatravels

Welcome to Busan Korea .. the location for KSBMB .. and apparently that breeding colony you’re having problems with (presumably the kimchee is key) …

To begin to undercover immune cell diversity, we partnered with @ImmGen_ to use our low-input automated CUT&RUN platform to process >1,100 samples and generate chromatin profiles from 94 cell types, including ultra-rare cell populations. Explore here! hubs.la/Q02yR7Fr0

Hong Kong airport walking to gate 447 / bugger …

Chania Crete for Aegean Conference ! Going to guess the local Mouse population is minuscule and edgy ..

22x Chromatin Readers dissected for their histone nucleosome binding by biochemical, proteomic and genomic approaches - major biological insight revealed [!] ..[biorxiv.org/content/10.110…] EpiCypher, Inc. Musselman Lab Neil Kelleher