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Verve Therapeutics team is thrilled today to present initial data from the Heart-2 Phase 1b clinical trial of VERVE-102, an in vivo base editing investigational medicine targeting PCSK9 And the emerging product profile of VERVE-102 (for patients receiving ≥50mg total RNA dose): a. A

How to make biology faster: - More speedrunning competitions and hackathons - Higher expectations for service providers (the "boring" stuff) - Spend lots more money funding people to build predictive models & in silico simulators. New from Stephen Malina. I love the header image, too.

Riveting scenes from the HBO medical drama The Pitt (Ep #2) depicting a #sicklecell pain crisis -- and the immediate staff suspicion surrounding the same.

Cover story in GEN Biotechnology: Bringing clarity and precision to the cell-free space by introducing 'exozymes' as a scientific nomenclature. Dr. Tyler Korman (Tyler Paz Korman), co-founder and VP of Research at eXoZymes states, “By introducing exozymes as a common terminology, we

Watch our team explain how you can use the FutureHouse Platform to come up with new hypotheses and make new discoveries.

I have a smorgasbord of (signed!) foreign translations to give away free -- reply or DM if you see anything: Breakthrough (1995) 🇬🇧 Cracking the Genome (2001) 🇸🇦🇯🇵🇨🇿🇵🇹🇸🇪🇪🇸🇳🇱🇩🇪🇮🇹 The $1,000 Genome 🇰🇷🇧🇷 Editing Humanity 🇯🇵🇷🇺🇮🇹🇰🇷

Introducing Finch, a new agent that fully automates data-driven discovery in biology. We are launching a closed beta for it today (sign up below). This is still early, but impressive, maybe similar to a good 1st yr grad student. In the video, see how it independently reproduces

Natalie Portman To Play Pioneering DNA Scientist Rosalind Franklin In ‘Photograph 51’ For Director Tom Hooper & FilmNation — Cannes Market Hot Project Deadline deadline.com/2025/05/natali…

Read the full preprint below 👇 If you're interested in the interface of bioengineering, DNA and virtual cell foundation models, and agentic reasoning, shoot me a note. We're hiring postdocs and ML researchers and starting some crazy new projects biorxiv.org/content/10.110…

ASGCT 2025: World’s First Patient Treated with Personalized CRISPR Therapy — Fay Lin, PhD reports on the breaking news from Kiran Musunuru Fyodor Urnov and colleagues just published in NEJM genengnews.com/topics/genome-… via Genetic Engineering & Biotechnology News

Today in Science Magazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with Sternberg Lab. 1/13 drive.google.com/file/d/1I-UbCR…

With the exception of KJ’s n-of-1 ABE (which alone was wonderful, beautiful, & inspiring enough to make it a memorable year), #ASGCT25 was rather bland, perhaps fittingly so given C&GTx’s challenges Despite that, wanted to highlight random tidbits that caught my eye $XBI (1/10)

Website from Harvard University outlining threats to lifesaving research from cuts to biomedical funding. Please share. harvard.edu

Global Observatory Gathers to Expand Debate on Human Genome Editing Experts are gathering to debate heritable genome editing. To mark the event, The CRISPR Journal published 18 invited Perspectives from participants. Kevin Davies Mary Ann Liebert Inc Global Observatory for Genome Editing hubs.li/Q03nz2qv0

First Personalized CRISPR Gene Editing Therapy Patient Baby KJ Discharged — excellent piece by Jonathan D. Grinstein, PhD on the latest milestone for the baby who made gene editing history insideprecisionmedicine.com/topics/precisi… via Inside Precision Medicine

The Eagle Has Landed: The family of Baby KJ saved by gene-editing therapy Speaks to the TODAY today.com/video/baby-kj-… via TODAY

Publishing peer review files at ⁦nature⁩ has been optional since 2020; starting Monday, it is automatic. share.google/7jLPyHU1x7UqNg…

Gene 🧬 edited pigs for PRRS virus resistance - was interviewed for this earlier this year - great 1st FDA approved food animal product Ag&Natural Resources UC Davis bbc.com/storyworks/the…

Solution Building: Merck Avoids One-Size-Fits-All Approach to AI and ML Great to see this exclusive Genetic Engineering & Biotechnology News interview with Iya Khalil Merck conducted at BIO by my colleague Alex Philippidis genengnews.com/topics/artific… via Genetic Engineering & Biotechnology News

PCR, restriction cloning, Golden Gate. So many core DNA techniques started with a natural enzyme then figured out a use for it Has anyone tried to reverse engineer this? Is there a wishlist of plausible DNA enzyme activities that, if they existed, would be the next CRISPR?