🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Patient Dies in Danon Disease Gene Therapy Trial Rocket Pharmaceuticals acknowledged the death of a patient in a pivotal trial assessing its Danon disease gene therapy candidate RP-A501, a study that the U.S. FDA has placed on clinical hold. #GeneTherapy hubs.li/Q03prKby0

Genetic Links for Common Inflammatory Arthritis Open Treatment Options The first systematic genome-wide association study for pseudogout has identified two genes strongly associated with disease progression MedUni Wien #DrugDiscovery #arthritis #GWAS hubs.li/Q03prHF50

T Cell Memory May Explain Chikungunya-Linked Chronic Pain How CD4+ T cells respond to Chikungunya virus may trigger long-lasting joint pain, mimicking autoimmune disease long after infection clears La Jolla Institute #InfectiousDisease #AutoimmuneDisease hubs.li/Q03prK9m0

Conquering the Complexities of AAV Manufacturing: Advances in Efficiency, Scalability, Compliance GEN talked with several CDMOs and/or CROs about new ways they are addressing AAV manufacturing challenges. PackGene Biotech Charles River Labs Lonza #AAV hubs.li/Q03prQ2j0

Synthetic Biosensor Monitors Drugs In Vivo Over Time Stanford University researchers suggest SENSBIT offers a potential foundation for implantable sensors that could aid precision medicine and health monitoring. #biosensor #DrugDelivery #PrecisionMedicine hubs.li/Q03prSjR0

Wacker and Expression Manufacturing Partner to Advance Lentiviral-Based Gene and Cell Therapies #ExpressionManufacturing and #WackerBiotech US plan to provide clients with a seamless, fully integrated production pathway #Cell #GeneTherapy #bioprocessing hubs.li/Q03prTS_0

Immuno-Safety Evaluation: Translational Cytokine Release Syndrome Assay for CAR T Development JAX’s platform helps #drug developers by improving preclinical CRS risk predictions, but also accelerates the development process. Sponsored by The Jackson Laboratory hubs.li/Q03pH5_V0

More Mutations in Childhood Cancer Might Mean More Therapy Options Increased genetic complexity and similarity to adult #cancers’ genetic diversity may also present new therapeutic opportunities Wellcome Sanger Institute Cambridge University PrinsesMáximaCentrum #pediatric hubs.li/Q03pHgc60

Base Editors Curb Repeating DNA in Huntington’s and Ataxia Models Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological disease David R. Liu Broad Institute Mandana Arbab #GeneEditing #DNA hubs.li/Q03pHq9Q0

Absci Advances Lead AI-Designed Candidate for IBD into the Clinic The trial is designed to assess the antibody’s ability to treat IBD by targeting tumor necrosis factor-like cytokine 1A (TL1A). #IBD #ArtificialIntelligence Absci hubs.li/Q03pHrHy0

BioAgilytix Expands Global CMC Analytical Services BioAgilytix officials say the company's expansion strengthens its ability to support biopharma partners at every stage of development. #bioprocessing #biopharma hubs.li/Q03pHzFH0

Nuclera and Cytiva Collaborate on Protein Characterization for Drug Development Proteins represent 95% of drug targets designed to combat disease, according to Yvonne Tan, PhD, from Nuclera. #bioprocessing #DrugDevelopment hubs.li/Q03pHDzk0

Accelerating Antibody Discovery Using an AI-Augmented Single B-Cell Screening Platform Q&A: Bob Chen, OmniAb VP of Discovery Systems, explains how the xPloration platform works and can be applied in #antibody discovery Sponsored by OmniAb #drug #AI hubs.li/Q03pQnXJ0

New Spatial Technology Unveils Nanoscale Genome Structure Associated with #Aging Latest imaging method from the Broad Institute uncovers structural disruptions in the nucleus associated with progeria at super-resolution Jason Buenrostro #genomic zack chiang hubs.li/Q03pX0zr0

PEG Alternative Minimizes Immunogenicity from LNP-Based Therapies The new material developed at Cornell University could significantly improve the delivery and effectiveness of mRNA vaccines. Shaoyi Jiang #mRNA #vaccine #DrugDelivery hubs.li/Q03pX2bd0

Gene Editing Marches On Despite Missed Beats Current setbacks cannot prevent gene-editing companies from advancing closer to “one-and-done” cures and new products. Sangamo Therapeutics Giuseppe Ciaramella Beam Therapeutics Inscripta, Inc. #GeneEditing hubs.li/Q03pX6X40

Neurodegeneration Slowed by Sleep Aid That Reduces Tau Buildup Mice treated with the sleep aid had less brain damage compared to controls and mice that received a different sleep drug. #DrugDiscovery #neurodegeneration #sleep WashU Medicine David Holtzman hubs.li/Q03pY60T0

Old Vaccine, New Tricks: PIE-seq Reveals How BCG Reprograms Immunity Decades-old TB #vaccine turned #cancer therapy may unlock new immunotherapies by reprogramming immune cell development in the bone marrow #tuberculosis Memorial Sloan Kettering Cancer Center Weill Cornell Medicine hubs.li/Q03pYFGs0

Single-Use Continuous Bioprocessing Can Reduce mAb Production Costs Ranjit Ranbhor, PhD, scientific advisor at the intellectual property law firm Pergament & Cepeda, spoke to GEN. #bioprocessing #ArtificialIntelligence #biomanufacturing hubs.li/Q03pNDsg0

Cutting CAR T Costs via Decentralization, Vector-Alternatives, and Artificial Intelligence The fundamental problem is that CAR T production is not a good fit for centralized manufacturing. #ArtificialIntelligence #bioprocessing hubs.li/Q03pNS9c0