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Guideline glance: The MHRA has produced a document outlining considerations for prescribers and patients when taking GLP-1 medications for weight loss and/or diabetes. We've summarised the information on GPnotebook. Find out more at: eu1.hubs.ly/H0lv6kV0

According to guidance, patients converting from 24-hourly modified-release morphine to transdermal fentanyl should apply the patch 12 hours after taking the final 24-hourly morphine dose. Find out more information on this topic at GPnotebook: eu1.hubs.ly/H0ly-vx0

An analysis of two large prospective cohort studies found that exercising ≥150 minutes weekly was associated with reduced rates of all-cause, cardiovascular and cancer mortality when compared with inactivity. Find out more at GPnotebook: eu1.hubs.ly/H0lBGpf0

Following the recent heatwave, and with more hot weather to come, this is a good opportunity to review our previous podcast by Dr Roger Henderson on heat exhaustion and heatstroke – including their differences, treatment and referral. See: eu1.hubs.ly/H0lFFc70

In this week's episode of GPnotebook TV, Anish Kotecha discusses the recently published NICE guidance on overweight and obesity management, focusing on assessment and communication approaches. Gain CPD by watching at GPnotebook: eu1.hubs.ly/H0lJ6K_0

Stat spotlight: In a study of metabolic dysfunction-associated steatohepatitis (SH), 62.9% of patients receiving semaglutide had resolution of SH without worsening of fibrosis vs. 34.3% with placebo. See: eu1.hubs.ly/H0lJ6rh0

Guideline glance: NICE has stated that relugolix–estradiol–norethisterone can be used, within marketing authorisation, as a treatment option for endometriosis symptoms in adults of reproductive age who have had previous treatment for endometriosis. See: eu1.hubs.ly/H0lHHM_0

Study evidence has shown that varenicline, when added to brief cessation counselling, is well tolerated and promotes nicotine vaping cessation compared with placebo among youths with addiction to vaped nicotine. See: eu1.hubs.ly/H0lJ7nY0

Did you know? Ideally, pneumococcal vaccine should be given 4 to 6 weeks before elective splenectomy or initiation of treatment such as chemotherapy or radiotherapy. To find out more on this topic, visit: eu1.hubs.ly/H0lNZDP0

In this week's episode of GPnotebook TV, Anish Kotecha summarises the changes required when prescribing short-acting beta 2 agonists in asthma, following a recent MHRA update and the revision of UK asthma guidelines in 2024. Gain CPD by watching at: gpnotebook.com/tv/respiratory…

Stat spotlight: Studies have shown that, when compared with morphine, 7-OH-mitragynine (derived from kratom) has ~13 times the affinity for opioid receptors. Find out more at GPnotebook: eu1.hubs.ly/H0lS8Qt0

The NHS Cervical Screening Programme was updated in 2025. It aims to reduce the incidence of and mortality from cervical cancer through a systematic, quality-assured population-based screening programme for people aged 24.5 to 64. See: eu1.hubs.ly/H0lS92d0

Testicular cancer spreads to retroperitoneal lymph nodes in 10–20% of patients and can cause back pain, nausea, bloating and enlarged veins in the scrotum. If spread to the lungs, it can cause breathlessness, cough, chest pain or haemoptysis. See: eu1.hubs.ly/H0lVc7t0

Did you know? If untreated, gonorrhoeal infections may spread to the epididymis and/or testes causing epididymo-orchitis, or to the endometrium, fallopian tubes and/or ovaries, causing pelvic inflammatory disease. Find out more at GPnotebook: eu1.hubs.ly/H0lYx220