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It’s out! Extrodinary work from Rachel Jansen Rachel Jansen is out today in Science Advances Science Advances

mTORC1 led us to lysosomes and in turn to develop LysoIP. In a tour de force of tech development and detective work Monther Abu-Remaileh and Nouf Laqtom take LysoIP in vivo and deorphan the function of the Batten Disease gene CLN3. nature.com/articles/s4158… nature

Feeling proud… nature.com/articles/s4146…

Our paper is online!! #SignalingProfiler is a novel method that allowed us to discover the key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients nature.com/articles/s4137…

Congratulations to Wonyul on his new study just published in Science. See science.org/doi/10.1126/sc… to learn more about how endosomal lipid signaling reshapes the ER to enable cells to burn fats in mitochondria in response to amino acid starvation and how this relates to disease.

Glad to see this out. New work providing a structural explanation for TFEB strict dependence on RagC activation state. See thread below👇 Congratulations Zhicheng Cui | 崔志成 and Hurley Lab for unveiling this beautiful structure.

Get rid of these ridiculous time scales! Surely selecting for people rushing their careers to fit this mould doesn’t help create a creative, healthy and robust research atmosphere #AcademicTwitter

Another piece of the TFEB regulation has been identified by Marcella Cesana and colleagues from the Andrea Ballabio's lab in collaboration with Diego Medina, Davide Cacchiarelli and the Tigem #BioinformaticCore Read the full article here: journals.plos.org/plosbiology/ar… marcella cesana

So glad to see my drawing associated with this beautiful paper!

Apply to the call and enjoy our team!

There is still time for abstract submission! Please, share! 😊

An ‘Awesome Lysosome’ meeting to honor Andrea Ballabio’s 30yrs as leader of the Tigem Telethon Institute 🇮🇹🍾

Proud of working with this wonderful group of young scientists. Gala dinner Tigem Telethon retreat

Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui Zhicheng Cui | 崔志成 using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ Gennaro Napolitano, A. Esposito, and A. Ballabio.

Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

Thank you Sergei Grivennikov for hosting me and for arranging such a beautiful day at Cancer at Cedars-Sinai Cedars-Sinai. Lots of stimulating conversations and funny moments!

Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain Aakriti Jain and amazing collaborators Rushika M. Perera, Guido Bommer, Charly Craik and James Olzmann: science.org/doi/10.1126/sc…

Happy to see our review out now in Nature Reviews Cancer was fun to co-create this piece with Matthias Valentina and Georg. we aimed to be as contemporary in coverage and forward-looking in outlook on protein degraders mechanisms and cancer therapeutics. nature.com/articles/s4156…

Excited to share the N&V Roberto Zoncu and I wrote for NatureStructMolBiol on the recent surge of LYCHOS structure papers! 🚀 We propose a unifying model that ties together these new discoveries. It’s incredible to see so much momentum building on our work. nature.com/articles/s4159…

Big News: Thrilled to share that my latest PhD work is now published in nature. We identify PLA2G15 as the lysosomal BMP hydrolase and show that blocking it improves outcomes in a severe neurodegenerative disease model. Read the article here tinyurl.com/3b9zt5fw (1/7)