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The Polsky Urologic Cancer Institute of the Lurie Cancer Center of Northwestern at NMH has chosen six faculty members to receive the Research Award to support clinical, laboratory or translational projects to advance knowledge & innovative research in the field of urologic #oncology.

Effects of Small Molecule Ligands on ACKR3 Receptors molpharm.aspetjournals.org/content/early/…

The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron | Nature nature.com/articles/s4158…

So excited to be part of this wonderful collaborative team with Michael R Tadross to develop and use new chemical probes to study CNS functions.

Climbing cancer’s MYC mountain go.nature.com/3A9tSSm MYC, one of the most commonly dysregulated proteins in cancer, has long seemed ‘undruggable’. Can a clinical-stage cell-penetrating peptide — or preclinical small-molecule inhibitors and degraders — prove otherwise?

When your research interests collide! IDO meets protein degradation. #ChemTwitter #MedChem #IDO #ProteinDegradation #PROTACs #CancerResearch pubs.acs.org/doi/10.1021/ac…

So grateful to the Prostate Cancer Foundation for their continued support of our MYC inhibitor project. Look forward to translating this to the clinic to help patients with prostate and other cancers.

Excited to share our recent publication Journal of Clinical Investigation on a novel class of small molecule compounds targeting Plek2-Akt interaction to treat #MPN. jci.org/articles/view/…. The diagram summarizes it all.

Getting ready for a great day of science and discussing our MYC inhibitor program with ⁦Sarki Abdulkadir⁩

Great presentation by ⁦Sarki Abdulkadir⁩ discussing our MYC inhibitor project. Very exciting to see this work discussed with the biotech/VC community.

Happy to share this latest work in collaboration with Daniela Matei to develop degraders of TG2, a multifaceted cancer target well-suited to PROTACs. Northwestern Chemistry, Lurie Cancer Center. pubs.acs.org/doi/10.1021/ac…

This is a fantastic opportunity with a terrific PI who is committed to doing truly impactful cancer research.

I am hiring 1-2 postdocs in #medicinalchemistry to work on #PROTAC and inhibitor projects as part of highly interdisciplinary collaborations with biologists and others. Please send a CV to apply to [email protected] to apply.

Congrats to M4 Northwestern Feinberg School of Medicine student, Erik Rabin, for his new publication, 'Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma'. sciencedirect.com/science/articl… Theresa Walunas, PhD, FAMIA Gary Schiltz SNO Pilar Sánchez-Gomez American Brain Tumor Association Erica Power Miri Kim Cancer and Aging Research Group (CARG) #GeriOnc National Cancer Institute

Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma: pubmed.ncbi.nlm.nih.gov/38600951/ National Cancer Institute American Brain Tumor Association Pilar Sánchez-Gomez Theresa Walunas, PhD, FAMIA Gary Schiltz NIH The National Institute on Aging (NIA) NINDS SNO ACS Research GBM Foundation Cancer and Aging Research Group (CARG) #GeriOnc AACR Cancer Research Institute Campillo Manon

In this episode of our #BreakthroughsPodcast, Sarki Abdulkadir discusses the discovery of compounds that block the 'undruggable' MYC gene, making #ProstateCancer tumors sensitive to hormone therapy. 🔗 spr.ly/6019o8Iml

Pleased to share new work describing the most potent human IDO1 PROTAC to-date with a DC50 of 4.5nM: biorxiv.org/content/10.110… To learn more, please visit: linkedin.com/feed/update/ur… Gary Schiltz AACR Cancer Research Institute Society for Immunotherapy of Cancer Lijie Zhai Prashant Bommi Taylor Koch ACS Research

ILLINOIS PRESIDENTS CUP CHAMPIONS ‼️🏆🏆🏆🏆🏆🏆🏆🏆 Congratulations to Coach Kieran & the 2011 GIRLS GA-R team who were crowned the U14 Illinois Presidents Cup Champions after a thrilling 2-1 OT victory over North Shore Elite! 💪🔥 These girls left it all on the field and