(1/2) It's finally out!--a new mechanism to treat brain cancers, where (nano)materials cross an intact blood-brain barrier! Thanks to…nature.com/articles/s4156…

You may think this could be a fake, but it is real. Surprisingly, Protein Science contacted us after publication!

Well done Changhao! It was such a pleasure working with you on this exciting project!

Super interesting and important study

Featured today by MSK Library: CD19 CAR antigen engagement mechanisms and affinity tuning dx.doi.org/10.1126/sciimm… Changhao He Jorge Mansilla-Soto Hamieh Mohamad George Khelashvili @Michel_Sadelain Science Immunology

Great work, Hengyi!

Congratulations Olga Boudker of Weill Cornell Medicine, newly inducted #NASmember! #NAS160 #biophysics #biology

Last night's lab watch party to see Olga Boudker signing the National Academy of Sciences Registry of Membership - we're so proud 🥹 #NAS160

How the dynamics of a cell component protein prepare the functional states of cholesterol cargo release in a vectorial transfer process. frontiersin.org/articles/10.33…

Very excited to share our latest collaborative work with Filippo Mancia and Rosemary Cater, PhD on MFSD2A lysolipid transporter! Using simulations and machine-learning we uncover how substrate binding to MFSD2A mechanistically triggers the protein occlusion. rdcu.be/dd6Zl

Check out our latest work on blood brain barrier #Omega3 transporter MFSD2A! 🐟➡️🧠 Nature Communications This work led by George Khelashvili reveals how substrate enters, occlusion occurs, and the role sodium plays in this! Filippo Mancia Columbia Vagelos College of Physicians & Surgeons Weill Cornell Medicine bit.ly/43xs2aP

Hey you GPCR aficionados, don't miss this great meeting held in beautiful Melbourne! 🇦🇺🐨🦘🌏

This project has been a dream since grad school. Exciting to see it come to fruition! Zhi and Melanie Odenkirk did amazing work, and the data is super cool! They were able to measure lipid binding affinities of natural lipids in bilayers on a lipidomic scale. Check it out:

Fabulous work from Rosie Cater, Filippo Mancia and all involved. CryoEM structure and functional studies of choline transporter FLVCR2 in the blood brain barrier. Rosemary Cater, PhD Filippo Mancia biorxiv.org/content/10.110…

What a great collaboration with our Cornell colleagues in Ithaca! Exciting work on fundamental principles governing Sars-Cov fusion peptides engaging with host membrane to trigger the viral fusion. The paper has been highlighted as ACS Editor's Choice! pubs.acs.org/doi/full/10.10…

Check out our latest work on automated collective variable detection from molecular dynamics simulations.

Postdoctoral position in computational biophysics, machine learning, and structural biology is open! Please see details in the attached.

Biao Qiu Check out the never seen before "semi-open" state, with L-Cys bound but before the last sodium ion (Na2) binds and closes the gate.

We are excited to release Constant-pH Simulator to setup constant-pH simulations with various packages. We thank to Jana Shen and Anton Jansen & Pavel Buslaev for their help with AMBER and GROMACS! charmm-gui.org/input/cph youtube.com/channel/UCtHN7…