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Thanks, Omer.

Our latest work, led by Benjamin Jackson and Angela Montero Memorial Sloan Kettering Cancer Center demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells

#RedoxBio25 Announcement! 🚨 Exciting opportunity for early career researchers! 🎉We have complimentary registrations available! Don't miss out - apply now! ➡️ bit.ly/4cSV0qZ

ICYMI in Nature Cell Biology 🔖 CRI's Gerta Hoxhaj Lab, Dohun Kim & colleagues have discovered how mitochondria use NADPH to fuel fatty acid synthesis, lipoylation. Read more about the biochemical method they developed ➡️ cri.utsw.edu/hoxhaj-lab-dis… #relentlessdiscovery

Fantastic structural-functional work on a giant stress-regulatory E3 ligase by Rapé Lab & team Molecular Therapeutics Initiative!

🚨 New in Nature Communications: We present a spatial multi-omics platform that maps the metabolome, lipidome, and glycome from a single brain section. Combining MALDI imaging with our computational tool Sami, we reveal metabolic diversity in health and Alzheimer's disease. 🔗

Happy to share our new paper demonstrating optimization of base editing to correct the lethal ACTA2 R179H mutation in human smooth muscle cells in vitro and humanized mice, thereby rescuing multisystemic smooth muscle dysfunction syndrome. ahajournals.org/doi/abs/10.116…

Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at Cell! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below👇

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

"We need really bright people and we need bold ideas." We're all in on making a proven positive impact. With the V Foundation, 100% of direct donations go to the best researchers and their revolutionary ideas. #NationalCancerResearchMonth

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

We are hiring! The Ardehali lab at UArizona Sarver Heart Center and UA College of Medicine – Tucson is hiring postdocs and technicians. Our research focuses on metabolism, Immunology, iron biology and cardiovascular disease. Interested applicants can contact me directly.

Congratulations to Renata Goncalves and everyone who contributed to this amazing work! CoQ imbalance drives reverse electron transport to disrupt liver metabolism nature.com/articles/s4158… Gökhan Hotamışlıgil Harvard University Harvard T.H. Chan School of Public Health Harvard Molecular Metabolism

Thrilled to share that our latest study is now published in nature! Grateful to our amazing collaborators at Hotamışlıgil Lab and Harvard Molecular Metabolism. nature.com/articles/d4158… nature.com/articles/s4158…

Excited to share our latest study from the Manning Lab. We have developed and characterized a novel mouse model lacking the five AKT phosphorylation sites on the TSC2 protein, which are critical for AKT-mediated activation of mTORC1 signaling.

Excited to share our Scintillon Institute Scripps Research latest work “A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt”: biorxiv.org/content/10.110… When we started working with NADH reductive stress (elevated

My lab's first paper is out in nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…

Momentous day for CRI DeBerardinis Lab postdoc & UT Southwestern Pediatrics Neonatologist Walter W. Chen, MD, PhD 🎉 recipient of a 2025 Burroughs Wellcome Fund Career Award for Medical Scientists! 👏👏 He will continue his #relentlessdiscovery studying uncharacterized organellar proteins ⬇️ cri.utsw.edu/deberardinis-l…