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#immunotherapy is a game-changer in cancer, yet dismal results have been observed so far in RCTs exploring its efficacy in high-grade #glioma In this systematic review, we delve into the possible underlying culprits. Giacomo Sferruzza Fedele Dono Marina Romozzi rdcu.be/dxKp3

The annual RRFS representative meeting of the European Academy of Neurology European Academy of Neurology hosted in #Porto just came to an end. Honored to be part of this wonderful community and work together towards shaping the future of Neurology Alice Accorroni Luca Cuffaro Giacomo Sferruzza

Great news in neuro-oncology! Vorasidenib has received fast-track designation from the FDA. Following the outstanding results of the INDIGIO trial, we hope it will soon be available for patients. #NeuroOncology #FDAApproval #Vorasidenib abta.org/mm-first-targe…

GPT-4 can also accurately annotate cell types in single-cell RNAseq 🤦‍♂️... guess that if you can't beat it, it's better to join it #AI #ChatGPT nature.com/articles/s4159…

Honestly I'm surprised it wasn't already known that... I bet if the authors analyze the brains of these mice, they'll find increased neurogenesis in the main niches and reduced hallmarks of aging #nature #aging #immunesystem nature.com/articles/s4158…

CAR-T for autoimmune diseases. We can discuss cost-effectiveness extensively, but for all 15 patients ‘immunosuppressive therapy was completely stopped’. This marks a significant turning point in autoimmunity. nej.md/3UMQcMH #nejm #cart #autoimmunity

We just wrapped up a two-day #RRFS office meeting where we discussed new opportunities for young neurologists and plans for #EANCongress in Helsinki 2024 and Seville 2025 🧠 💙 European Academy of Neurology

Excited to share the work of my friend, Gianmarco Abbadessa, which raises many questions about the dynamic maintenance of (dysfunctional) T cell responses. Looking forward to discussing over a glass of wine!

In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy go.nature.com/4cfyac2

Our first in vivo primary NK screen that discovered new NK cellular checkpoints. Kudos for team for their 5 years of work. nature.com/articles/s4158… Yale Department of Genetics Yale School of Medicine Yale West Campus Yale Cancer Center Yale Center for Biomedical Data Science (CBDS)

I'm very glad to have had the opportunity to work on this amazing project. The technological efforts of the sidichenlab to discover new NK cell checkpoints open new therapeutic directions for immunotherapy against solid tumors!#immunotherapy

Sidi Chen Lupeng Ye Yale Department of Genetics Yale School of Medicine Yale Center for Biomedical Data Science (CBDS) Yale West Campus Boosting ‘natural killer’ cell activity could improve cancer therapy #NBTintheNews via Yale University news.yale.edu/2024/06/25/boo…

Come to our #RRFS Booth during the #ean2024 to learn about opportunities for residents and PhD students in neurology and to get free brain tattoos! 🧠 💙 European Academy of Neurology Alice Accorroni Dra Alicia González Martínez Giacomo Sferruzza Luca Cuffaro

Today, we passed the baton to our new EAN Board members! A heartfelt thanks to our outgoing members for their dedication. Here’s to new beginnings and advancing neurological excellence across Europe and beyond! 🎉 #EANBoard #EANeurology #Neurology #BrainHealth #Collaboration