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💚Available meds for nephro protection and their potential mechanisms 🛡️SGLT2i #flozinate 🛡️GLP-1RA #glipinate (?) 🛡️MRAs 🛡️ACEi #Nephmadness Gila The NephMadness Monster 🦎

Hi! With tonight's #nephjc there will probably not be any dilemma we will become all #glipinators Which one you like more? Poll in the comments👇

Hi #NephJC I am the official #NephMadness Gila Monster who in retrospect, unexpectedly won 👑🦎 I am here to say, what I said months ago #glipinate (no COI, it's in my nature to glipinate) 👉Here is my CV ajkdblog.org/2024/03/01/nep…

Hi! Cristina Popa here, 🇷🇴 nephrologist, no COI🦎 #nephjc I feel extremelly lucky I could live tweet from ERA - European Renal Association FLOW trial session Plus I managed to finish this pic, reflecting how I imagined Gila The NephMadness Monster during #nephmadness

Treating DKD, we have come a long way in just the last few years… RASi, nsMRA, SGLT2i/flozins… but look at the residual risks even with current medications. We know we can do better! #NephJC Slide from #ERA24

Nephrology Journal Club 93% had high risk and very high-risk #nephjc

So, let’s open the spigot on the results! #NephJC We avoided this question until now.🫣 Wonder where the FLOW acronym comes from?🙃 So did we, until we heard it on the Freely Filtered: A NephJC Podcast podcast. nephjc.com/freelyfiltered…

More nephro protection #GoWithTheFlow Gila The NephMadness Monster🏆 #NephJC kidneynews.org/view/journals/…

T0f We stop to remember 2024's #NephMadness winner. There were fervent discussions, disbelievers & calling it a #BlueRibbonFail. Gila was the key to DPP-4i and GLP1-RA development! #NephJC 🦎@drkeeksphd Tiffany Truong Gila The NephMadness Monster VA by Cristina Popa 🦋 ajkdblog.org/2024/03/01/nep…

see the SGLT2i and semaglutide interaction in FLOW nature.com/articles/s4159… consistent effect regarding mortality, MACE and slope in GFR Vlado Perkovic Steno Diabetes Center Copenhagen

🍯Diabetic kidney disease is not past hyperglycemia. Now we are at the point when we have more than one therapeutic option 🤔How do we choose? Or do we choose? 👇Pathophysiology gets us closer to precision nephrology Nature Reviews Nephrology pubmed.ncbi.nlm.nih.gov/38570632/

#glipinate 🦎

🦎Do u know the link between the VA Medical Center in Bronx, NY (my old stomping ground), Gila Lizard & GLP-1 RA? Endocrinologist, Dr Eng, at the Bronx VA isolated Exendin-4 from the Gila Lizard venom. The rest is history! #FLOWtrial nytimes.com/2002/09/21/bus…

Another life lesson, even with what is now considered a blockbuster discovery, Dr. Eng struggled to patent this drug. In fact the VA declined to do so stating that it did not address a veteran-specific ailment 🤯 #GLP1RA 👉🏽 diabetesincontrol.com/dr-john-engs-r…

Who called my name? #glipinate 😉

Fascinating new observation from #STEPHFpEF by Sanjiv J. Shah, MD & Mikhail Kosiborod #GLP1RA semaglutide leads to *outsized* reductions in diuretic needs in patients with HFpEF compared with other core medical therapies Article 🔗 academic.oup.com/eurheartj/adva… Editorial 🔗 academic.oup.com/eurheartj/adva…

Wow, another win for patients with #HFpEF and obesity! This time with dual incretin tirzepatide in #P3 #SUMMIT trial Co-primary endpoint of worsening HF events reduced by 38% HR 0.62 95% CI 0.41 to 0.95; P=0.026 investor.lilly.com/news-releases/…

Lurking incognito #KidneyWk Hope seeing as many as you at 1st late breaking clinical trials session to #glipinate and implicitly #flozinate 🎯see Effects of Semaglutide on Kidney Parameters in Patients with Obesity and Nondiabetic by Hiddo Heerspink 🎨Art by Brian Rifkin, MD

#glipinate

Well, well #glipination being number one in #TopNephrology warms my 🦎 heart Have you seen the logo? #nephjc