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$ARVN into phase 1 with a Kras G12D degrader, ARV-806. Let's hope it's better than $ALPMF ASP3082! clinicaltrials.gov/study/NCT07023…

Structural evolution progress of orally bioavailable selective estrogen receptor degraders sciencedirect.com/science/articl…

Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search | Journal of Chemical Information and Modeling pubs.acs.org/doi/10.1021/ac…

A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 nature.com/articles/s4158…

Research Progress in Targeting GSPT1: Molecular Glues, Bifunctional Degraders, and Antibody-Enabled Molecular Glues for Cancer Therapy | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders | ACS Central Science pubs.acs.org/doi/10.1021/ac…

Phosphotyrosine Mimetics Enable Selective STAT6 Degradation with AK-1690 | drughunters.com/3I877p2 Small molecule interference with the STAT6/IL-4/IL-13 signaling axis is gaining momentum, with multiple academic and industrial groups pursuing selective STAT6 inhibitors and

A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Design and Application of Cereblon-Recruiting Prodegraders | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole–nicotinamide chemotype pubs.rsc.org/en/content/art…

Expanding the reach of molecular glue degraders | Science science.org/doi/10.1126/sc…

Development of nanobody-based PROTAC (NbTAC) for ROR1 degradation by RNF149 sciencedirect.com/science/articl…

Chemical Proteomics Identifies RBBP7 as a New E3 Ligase Supporting Targeted Protein Degradation - Liu - Angewandte Chemie International Edition onlinelibrary.wiley.com/doi/10.1002/an…

Cool paper from Monte Rosa on Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition | Science science.org/doi/10.1126/sc…

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DNA-Templated Spatially Controlled Proteolysis Targeting Chimera for Cyclin D1–CDK4/6 Complex Protein Degradation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders onlinelibrary.wiley.com/doi/10.1002/an…

beauxarts.com/expos/le-grand…

How to Use Drug Hunter to Improve Design Ideas Tuesday, July 22nd, 2025 8 AM PT | 11 AM ET | 5 PM CET One of the most common questions during the design process for new drug molecules is whether a particular structural motif appears in FDA-approved drugs or recent clinical

Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…