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NEW in Chemical Science 📢 A Rapid and Sensitive Method for Chiroptical Sensing of α-Amino Acids via Click-like Labeling with o-Phthalaldehyde and p-Toluenethiol by Gong Chen et al. Read it here for free! 🔗 ow.ly/vLUS50D28IW

Very proud of this chemistry 🤪

Our first study on DNA-encoded library synthesis. The Pd-catalyzed S-arylation chemistry is very effective and robust under biocompatible conditions. Many thanks to Xiaojie Lu at SIMM for a great collaboration! - now published in Chemical Science pubs.rsc.org/en/content/art…

Simple FeCl2 catalyst enables a very efficient method to make N-N bond. A great collaboration with Prof Sukbuk Chang #KAIST. Please check out our latest research on #nitrene chemistry, published in Nature Chemistry

Check out @gongchenlab, Xiaojie Lu et al.'s latest article 😍⬇️ Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA 🔗 ow.ly/K5vm50E6bVZ

Very excited to have our collobaration work with Sukbok Chang selected as the Synfact of the Month! Thank you Mark Lautens OC and Chemistry at Thieme

Please check out this work if you are interested in C-glycoside synthesis. The next goal will be alkyl C-H glycosylation :)

Extendable stapling of unprotected peptides by crosslinking two amines with o-phthalaldehyde disq.us/t/44d05fd Our new chemistry for peptide macrocycles publishend on Nature Communications. Many thanks and Congrats Gong Chen.

It is a great pleasure to be part of this exciting work on Fe-catalyzed C-glycoside synthesis led by MJ Koh MJ Koh Group

Learn more about #Asymmetric C–H Functionalization in our Thieme Web #Cheminar with Joanna Wencel-Delord (joanna wencel-delord), Shigeki Matsunaga, Nicolai Cramer, and Bing-Feng Shi (Shi lab). Chaired by Liu-Zhu Gong and Gong Chen (Gong Chen). Register now 👉📝fal.cn/3onTo

Our lucky streak continued! Formaldehyde can glue amine and guanidine together like a charm :) Thank Xiaosong Xue at Nankai and SIOC for the computational collaboration! pubs.acs.org/doi/10.1021/ja…

I am deeply humbled and honored to be part of the editor team of Organic Letters. I very much look forward to serving the journal and our organic community☺️

Two simple reagents, HCHO and hexafluoroisopropanol (HFIP), unleash new chemical magic! HCHO effectively “sucks” the alpha C-H bond from common alkyl amines in HFIP solvent, enabling hydride liberation without metals or light. It works for complex systems, too.

N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh MJ Koh Group.

We are grateful for the swift publication of this work in Nature Synthesis and the outstanding editorial assistance received!

HFIP's magic shines again, enabling peptide stapling with alpha-ketoaldehydes through unique imidazolium linkers, outperforming natural “glycation” processes. We proposed HFIP aggregates act as a proton shuttle for efficient deacylative C--C cleavage.

Interested in sulfonium ylide chemistry? Don’t miss Biao Xiong's latest Organic Letters paper J Org Chem/Org Lett on a sleek Cu-catalyzed [3+2] route to 5-CF3-pyrroles, starting from CF3-imidoyl sulfonium ylides and terminal alkynes.

A huge thank you to our amazing guest editors, Masayuki Inoue, Lara Malins @Malins_lab, and Hans Renata Hans Renata, for organizing this OL special issue on radical-mediated reactions! Special thanks to Steve Ritter and Matt Saucier for your invaluable support.

We’ve been dreaming of this type of conjugation chemistry for years—and finally, a simple fix to a stubborn problem, all thanks to just a tiny drop of CS₂. Minimalist chemistry is the new gold. ✨