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Please check out the final version of our recent work on #myelin disease, neuroinflammation, and axon degeneration doi.org/10.1038/s41467… Thankful for a very constructive review process Nature Communications and amazing help Michael Coleman Emmanuel Saliba Universitätsklinikum Würzburg @SyNergy_Cluster et al

Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease nature.com/articles/s4146…

Efficient removal of abnormal #myelin allows survival of nerve fibers targeted by adaptive immune cells, according to a novel study Nature Communications by scientists Universitätsklinikum Würzburg Janos Groh Universität Würzburg #UniWürzburg TU München uni-wuerzburg.de/en/news-and-ev…

I’m going to present a poster in ASCB/EMBO this year. Stop by if you want to know about oligodendrocyte, one of the most powerful lipid producing cells in the body. Lots of beautiful EM, primary culture and lipidomics! #cellbio2023 #membranetrafficking #lipidtime

Proud to present our findings in Cell about neuronal STING as integrator of inflammatory and glutamate signals in #multiplesclerosis. Great work by Marcel Seungsu Woo , Christina Mayer , INIMS collaborators Merkler lab The Conrad Lab Markus Glatzel cell.com/cell/fulltext/…

In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage mediated by CD8+ T cells that promote the accumulation of interferon-activated myelin-damaging #microglia nature.com/articles/s4159…

🎉Excited to share that my PhD work is out Immunity. We show that epigenetic reprogramming via innate immune training with BCG vaccination or KO of HDAC1/2 in microglia enhances remyelination in aging, highlighting mechanisms of age-associated decline in myelin repair(1/1)

nature.com/articles/s4146… I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:

My first-author paper is out today Nature Communications ! We investigated how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in developing myelin and explored nonvesicular lipid transport involved. #lipidtime doi.org/10.1038/s41467… (1/n)

Happy to share this recent review with Mika Simons - White matter aging and its impact on brain function: Neuron cell.com/neuron/fulltex…

To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by Axel Guskjolen . We hope you enjoy every single piece of it as much as we do! cell.com/neuron/current

Now published in the June issue Nature Neuroscience I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover. #Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple. Thanks Elisa Floriddia & co!

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain nature.com/articles/s4159… Nature Neuroscience

New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains. Learn more: hubs.ly/Q03sqNtp0

Are T cells in the brain friend or foe? In tauopathy mice, CD8⁺ T cells can slow pathology. In older, wild-type mice, they damage the optic nerve. (@NINDSnews NIH @tumuenchen ow.ly/5yc650Wos1Y