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The BSCR is pleased to announce the launch of our ECR mentorship programme! Available to all BSCR members. To discover more, and sign up, head to the members area at bscr.org. Not a member? Join for access to this scheme and more! bscr.org/#memberships.

Vesicular transport in a bundle of neurons. Made this movie some years ago. Incredible how much material is constantly being moved around in our cells over long distances by tiny (nanometer scale) motor proteins #microscopy, #science, #cells_are_amazing

Labeling bio images just got 10x faster 🏎️ Watch our best AI model yet in action, released today as AI Detect on Biodock AI. You prompt one object, it finds the rest. Try it for free now!

CAPture, a centrosome affinity purification method for mammalian cells, is finally out🥳 sciencedirect.com/science/articl… We found that a short peptide of CCDC61/VFL3 can be used to isolate centrosomes / basal bodies cell lysates

Cancer drug could hold hope for treating #inflammatoryDiseases including gout and heart diseases Cambridge University Journal of Clinical Investigation doi.org/gs2842 medicalxpress.com/news/2023-11-c…

#Cover: PLK1 regulates NLRP3 inflammasome activation by controlling microtubule organization: buff.ly/3MmUEgj Xuan Li_Lab Marta Baldrighi Xiaohui Zhao Emily 🏳️‍🌈👩‍🔬 Murray Clarke Lab Guillermo de Cárcer @m_malumbres Ziad Mallat #CellBiology #Immunology

Check our paper published at JCI, featured as cover for this issue. Brilliant team members (Marta Baldrighi Christain Doreth Yang Li Emily 🏳️‍🌈👩‍🔬 …) and collaborators (Xiaohui Zhao Murray Clarke Lab Guillermo de Cárcer @m_malumbres Ziad Mallat…) for this collective effort. Thanks to British Heart Foundation .

We show targeting microtubules via pharmacological drugs to inhibit PLK1 could provide a treatment strategy for inflammatory diseases characterized by excessive NLRP3 activation. cam.ac.uk/research/news/…

Nature research paper: IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer go.nature.com/40oH0PI

This cover image for our research article jci.org/articles/view/… shows inflammatory macrophages with many NLRP3 signals (green) around the microtubule-organizing centre (microtubules in red). Taken by Yang Li & XC using Zeiss LSM980 with airyscan 2 ZEISS Microscopy

PoV: your main PhD paper is finally published but the Uni's comms office decides that your cell biology and immunology research is best represented by a *big ugly foot* 👣 Still super proud, though. Great team effort Xuan Li_Lab cam.ac.uk/research/news/…

VSMCs are efficient activators of IL-1β that do not use canonical inflammasomes or caspases. Hence, this alternative pathway could be targeted for long-term treatment of CVDs, as it is not central to everyday host defence Murray Clarke Lab European Atherosclerosis Society 🔗atherosclerosis-journal.com/article/S0021-…

N&V by Ben Prosser on the recent study by Christine Loescher, Johanna K. Freundt et al. pinpointing the contributors to #myocardial passive #stiffness. Penn Medicine|nature.com/articles/s4416… 👉rdcu.be/dqdpJ

Karolinska Cardiovascular Research Retreat 2023. Thanks José Javier Fuster Xuan Li_Lab lassefolkersen Carolina Hagberg and all participants. 🫀

Pleased to see our study is highlighted as the Editor's pick in JCI This Month. jci.org/articles/view/… jci.org/this-month/202… Thanks to British Heart Foundation

Little News and Views Xuan Li_Lab and I wrote. Still disappointed they didn't let us use the pun-tastic: You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help. doi.org/10.1038/s44161…

Only 3 weeks left to submit abstracts for our ECR symposium in Sheffield on 26th April! Head here for details and to submit your abstract: bscr.org/meetings/ecr24

👀 We are recruiting for a Research Assistant to work on novel therapeutics to mend the broken heart❤️‍🩹with stem cells🧫, RNA 🧬Come join us in fun, collaborative, interdisciplinary environment! 🧑🏻‍🔬👩‍⚕️👩🏻‍🔬 Catherine Wilson Dept. of Pharmacology, Univ. Cambridge CambridgeCardio Cambridge Stem Cell Institute VPD Heart & Lung Research Institute