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The local microenvironment drives activation of neutrophils in human brain tumors: Cell cell.com/cell/fulltext/…

The Gate lab is thrilled to share our latest publication, online today at Neuron. This study was led by two highly talented former research technicians, Abhi Ramakrishnan and Natalie Piehl (both now Driskill Graduate Program in Life Sci graduate students). I will outline key findings here:

Identification of direct connections between the dura and the brain | Nature nature.com/articles/s4158…

Congratulations to Hong-Gyun Lee for his study out today in nature! We describe epigenetic memory in ACLY+p300+ astrocytes that worsens MS pathology nature.com/articles/s4158…

Innate immune activation in neurodegenerative diseases: Immunity cell.com/immunity/fullt…

Adaptive immune changes associate with clinical progression of Alzheimer’s disease | Molecular Neurodegeneration | Full Text …arneurodegeneration.biomedcentral.com/articles/10.11…

And so it begins 🤩🤩🤩 Our annual neuroimmunology workshop organized by the CFNI thanks to our sponsors : France Alzheimer, France sclérose en plaques, Neuratris, société française d immunologie and Paris brain institute

What a blast! Two intense days of neuroimmunology advances with amazing speakers maria g castro Brain-Immune Communication Lab Jasmin Herz Michael Heneka Nicolas Fazilleau IMMCEPTION Lab . It was an honor to host you thanks to France Alzheimer et maladies apparentées France Sclérose En Plaques EATRIS Institut du Cerveau - Paris Brain Institute SFI Immunologie

Honored to share our latest Perspective article Nature Aging on The path to next-generation disease-modifying immunomodulatory combination therapies in Alzheimer’s disease. Inserm crsaparis Faculté de Santé de Sorbonne Université GHU Paris Psy-Neuro Université Paris Cité link.springer.com/article/10.103…

The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis biorxiv.org/content/10.110…

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis Nature Neuroscience nature.com/articles/s4159…

Amyloid-β-activated microglia can induce compound proteinopathies academic.oup.com/brain/advance-…

Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein | Science Immunology science.org/doi/10.1126/sc…

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science science.org/doi/10.1126/sc…

The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype | Acta Neuropathologica link.springer.com/article/10.100…

Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s4158…

Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs | Science science.org/doi/10.1126/sc…

Programming tissue-sensing T cells that deliver therapies to the brain | Science science.org/doi/10.1126/sc…

Neuroinflammation in Alzheimer disease | Nature Reviews Immunology nature.com/articles/s4157…

Excited to share our latest Nature Medicine study from our new center Abrams Research Center on Neurogenomics! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)