🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Classic #JAMA paper using #MetaRegression to establish that stopping #RCTs early for benefit on average overestimates treatment effects by 29% and creates spurious estimates of effect up to 38% of the time. #EBM #Medicine pubmed.ncbi.nlm.nih.gov/20332404/

The renaissance in #EBM and #GRADE continues: the third article in the #BMJ series presenting Core GRADE, the essentials of the GRADE approach to certainty of evidence and strength of recommendations. Today Core GRADE’s approach to addressing #inconsistency in results.

As previous post, a 2-minute video in which I describe the third of 7 Core #GRADE articles appearing in the #BMJ. This one, published today, addresses #inconsistency in #SystematicReviews and #Guidelines. youtube.com/watch?v=uLqKZZ…

This classic #GRADE paper from the era before GRADE got too complicated shows you how to create #SummaryofFindings tables for continuous outcomes and in particular patient-reported outcomes. #EBM #PRO #Medicine pubmed.ncbi.nlm.nih.gov/23116689/

Just published in #BMJ Evidence-based medicine what the authors describe as “key insights from an interview with #EBM scholar Professor Guyatt” regarding EBM’s development and future in China where I’ve been visiting regularly for over 20 years. pubmed.ncbi.nlm.nih.gov/40169188/

Before this classic #GRADE paper we thought we were rating certainty in the point estimate. In this 2017 #JCE paper, we announced our revelation: we are rating our certainty that the truth lies on one side of a threshold or in particular range. #EBM #Medicine

A series of 7 papers, Core #GRADE, the essentials of GRADE providing all you need to rate #CertaintyofEvidence and move from evidence to recommendations, is currently appearing in the #BMJ. Today, dealing with #RiskofBias, publication bias, and large effects. #EBM #medicine #CPG

As previous post, an 2-minute video in which I describe the fourth of 7 Core #GRADE articles appearing in the #BMJ. This one, published today, shows address #RiskofBias in #SystematicReviews and #Guidelines. #EBM #Medicine #RoB #SR Publication link: bmj.com/content/389/bm…

In this 11-minute video I use the example of our giant network #MetaAnalysis of all #diabetes treatments to explain the principles of #NMA. One commentary: This is a terrific overview that gets the point across in a remarkably straightforward way. #EBM #Medicine

If you want a truly comprehensive checklist following #EBM and #GRADE principles that will allow you to consider every possible step in creating a clinical practice #guideline, this paper, published in the #CMAJ, is it. pubmed.ncbi.nlm.nih.gov/24344144/

The classic ground-breaking, paradigm-shaking #NEJM article introduced the world to the potential for #RCTs in individual patients - #Nof1 RCTs - to improve #PatientCare. nejm.org/doi/abs/10.105…

Core #GRADE guidance today in the #BMJ addresses the essentials of evaluating #indirectness with respect to patients (old vs young), interventions (fully versus partially adherent), comparators (#placebo vs active) and outcomes (surrogate vs patient-important).

In this 2 minute video I summarize Core #GRADE guidance from today’s 5th article in our series in the #BMJ presenting the essentials of using GRADE – this one addressing #indirectEvidence (limitations in applicability or generalizability to the target #PICO at hand). Publication:

Just published classic #EBM demonstration of how a very large data base from an #ObservationalStudy can provide evidence to validate a #RiskPrediction tool: in this case, predicting venous #Thromboembolism in patients undergoing non-cardiac #surgery. pubmed.ncbi.nlm.nih.gov/40354313/

Ground-breaking, still highly relevant paper established that specific health status measurement #instruments are better at detecting treatment effects – that is, more responsive – than are generic instruments. pubmed.ncbi.nlm.nih.gov/12589870/

Are #RCTs addressing patient-reported outcome measures (#PROMs) showing trivial, small, moderate or large effects? Ground-breaking paper showed how to replace mean differences with a responder analysis identifying proportion of patients with an important benefit.

Today in #BMJ, 6th in 7 part series on the essentials of #GRADE – Core GRADE: creating excellent Summary of Findings tables allowing clinicians and guideline developers to easily and comprehensively grasp evidence that will assist patients to make optimal decisions.

In a 2 minute video I summarize Core #GRADE guidance from today’s 6th article in our #BMJ series of the essentials of using GRADE – this one addressing how to create optimal Summary of Finding tables that facilitate optimal #guidelines and shared decision making.

I would like to express my deep gratitude to three reviewers of the #BMJ Core #GRADE papers, Sheri Keitz, Ariel Izcovich, and Mark Helfand whose careful, meticulous, and insightful reviews had a huge positive impact on the series.

Paper just published in #BMJ_EBM paper provides additional details to one of the more challenging aspects of Core #GRADE: how to deal with the situation when certainty rating threshold is the null and point estimate near the threshold. pubmed.ncbi.nlm.nih.gov/40044276/