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Really excited to share our work on the fundamentals of non-specific binding in antibodies and the transition of molecular binding events to phase separation. Thanks to everybody involved! KnowlesLab Cambridge bioRxiv Novo Nordisk #targetspecificity #drugdiscovery #LLPS

One of the more interesting reads you will come across today!

Non-specificity as the sticky problem in therapeutic antibody development nature.com/articles/s4157… A Review from Tuomas P. J. Knowles, Nikolai Lorenzen and co-workers. Hannes Ausserwöger Matthias Schneider KnowlesLab Cambridge Paolo Arosio Cambridge Chemistry ETH Zurich Novo Nordisk

Magic bullet or generic sticker? Find out about antibody non-specificity in our recent work in Nature Reviews Chemistry!

Check out our new work in PNASNews on how surface patches control protein binding specificity: doi.org/10.1073/pnas.2… Great work by Hannes Ausserwöger, Georg Krainer, Tim Welsh, Ella de Csilléry, Tomas, Matthias Schneider and Therese in collaboration with Novo Nordisk and CCG_MOE.

Check our latest work on studying the mechanism of action of phase separation modulators by characterising partitioning. Great work by Hannes Ausserwöger, Daoyuan Qian, Georg Krainer, Tim Welsh with #StGeorgeHyslopLab Hyman Lab #AlbertiLab @PappulabWashU. doi.org/10.1101/2023.0…

Transformational insigshts into investigating multi-component systems in the new preprint by Daoyuan Qian, Hannes Ausserwöger and Tomas Sneideris in a fantastic collaboration with @PappulabWashU: biorxiv.org/content/10.110…

Excited by the possibility of proteins being able to generate distinct pH microenvironments without needing mebrane enclosure, active transporters or energy input! KnowlesLab Cambridge

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates: Cell cell.com/cell/fulltext/…