Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and Hong Yue and all co-authors on this story! 1/ nature.com/articles/s4158…

Thanks Jason Mast for covering our new work with Fischer Lab on DCAF5 in STAT today.

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2 dlvr.it/T54tGQ

The 20S proteasome plays a key protease role in many regulatory processes. Yet, how its ordered biogenesis and temporally timed catalytic site activation works has remained elusive. In our latest work, we provide evidence for how that occurs! NatureStructMolBiol rdcu.be/dElr4

Antibodies expand the scope of angiotensin receptor pharmacology | Nat Chem Biol doi.org/10.1038/s41589…

Excited to share bioRxiv in collaboration with Rachel Fearns at BU in which we determined the cryo-EM structure of the Nipah virus polymerase complex! The complex assembles with a tobacco pipe-like shape with a flexible stem (do you see it?)😃😅biorxiv.org/content/10.110…

Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of Molecular Cell! cell.com/molecular-cell… 1/n

STK19 is a bona fide transcription-coupled repair factor. Check out the preprint with Johannes Walter ➡️bit.ly/4fgl2Fq We achieved a major technical milestone: 1.9 Å resolution structure of an RNA polymerase II transcription complex. Txn goes sub-2 Å!

Congrats everybody, that took a while from the preprint 😅💪 nature.com/articles/s4158…

A new paper from Benjamin Ebert, Nathanael Gray, Eric Fischer, Fischer Lab, Yen-Der Li, Michelle Ma, and Muhammad Murtaza Hassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW

We are excited to share our Nature Communications paper by postdoc Pan Pan Yang and The PhD Program in Virology at HMS grad student Wanyu wy on the structural binding mode of eastern equine encephalitis virus (EEEV) and Semliki forest virus (SFV) with receptor VLDLR rb.gy/2ryjcu

Excited to share our most recent paper at Cell in which we used #CryoEM to study conformational dynamics as a determinant of drug selectivity and resistance for the herpes simplex virus DNA polymerase. cell.com/cell/fulltext/…

A nice piece on one our Cell papers published earlier this year about mechanisms of herpes simplex virus polymerase drug resistance related to conformational dynamics. 🕺 drugdiscoverynews.com/protein-confor…

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert tinyurl.com/setd2

1/n) Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and Alan Brown nature.com/articles/s4158…

Excited to share our bioRxiv led by Xiaoyi Fan and wy exploring how binding of western equine encephalitis virus (WEEV) to its cellular receptors evolved over the past century 🤩 biorxiv.org/content/10.110… Harvard Micro

Absolutely thrilled to share paper on Nipah polymerase in close collaboration with Rachel Fearns at Boston University Boston University. 😃We previously posted on bioRxiv but this is the print form Cell. 🦇 Harvard Micro Gates Foundation cell.com/cell/fulltext/…

Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: science.org/doi/10.1126/sc…

Excited about mechanistic biology and processes in the cell's nucleus? Join our lab as a post-doctoral researcher! We have a state-of-the-art cryo-EM facility at HMS, a brand-new lab space, and a vibrant community at HMS! DM/email me or check farnunglab.com

Excited to share our latest work led by our postdoc Dan Zhao! We uncovered how the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase (Pdi1) initiates ERAD. A long-sought ERAD reductase is finally discovered! nature.com/articles/s4159… Huge congratulations!