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⏳Only 4 days left to nominate! Do you know someone who has contributed through research, mentoring, advocacy, or leadership to the field? Give them the recognition they deserve! Nominate them for our professional awards before May 9! 🏆👉 ashg.org/membership/awa… #ASHG

📣New from Tang et al! 📄Integrating #spatialtranscriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypes 👉bit.ly/3GHEgak

🚨Online now! 📄The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans 🧑‍🤝‍🧑Minna Ampuja Emmi Helle & co 👉bit.ly/3RMBXoG

Systematic review and meta-analysis from Human Genetics and Genomics Advances latest article suggests that ∼11% of small cell lung cancer patients harbor likely pathogenic variants and argues for genetic testing in clinical care: cell.com/hgg-advances/f… #ASHG

This week marks 7 years of All of Us! We've built the nation's largest accessible biomedical data resource while delivering the world's largest return of individualized DNA research results. Watch our advisory panel public session to learn what's next: youtube.com/watch?v=oi6GvD…

📣Online now! 📄Two-sample bi-directional causality between two traits with some invalid IVs in both directions using GWAS summary statistics 👉bit.ly/4m4BZWL

📣New from Young et al. 📄Pathogenic PPP2R5D variants disrupt neuronal development and neurite outgrowth in patient-derived neurons that are reversed by allele-specific knockdown 👉bit.ly/43bjTda

🚨Online now! 📄Influence of Genetic Ancestry on Gene-Environment Interactions of Polygenic Risk and Sociocultural Factors: Results from the Hispanic Community Health Study/Study of Latinos 🧑‍🤝‍🧑 J Genevieve Wojcik, PhD MHS & co 👉bit.ly/3YB9R3y

📣New from McWalter et al! 📄The phenotypic spectrum of individuals with SLC16A2 variants in MCT8 deficiency 👉bit.ly/4k4JlrV

📣Online now! 📄Interaction between genetic risk and comorbid conditions in #endometriosis 🧑‍🤝‍🧑Sally Mortlock Isabelle McGrath & co 👉bit.ly/4jdu2Mw

11% of #patients w/ #SCLC have PGVs on #germline #genetictesting per systematic review & meta-analysis, #patients with P/LP variants in DNA damage response and repair genes have a trend for better overall survival. Similar to >14% #patients w/ #NSCLC having PGVs w/

The latest Human Genetics and Genomics Advances study examines the interaction of a polygenic score for BMI with sociocultural factors and genetic ancestry across groups in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): cell.com/hgg-advances/f… #ASHG #GeneticsDiscoveries #HumanGenetics

📣New from Henches et al! 📄Polygenic risk score prediction accuracy convergence 👉bit.ly/3SKenco

Mike Bamshad, MD, said it best — THANK YOU! The support of Human Genetics and Genomics Advances from our vibrant community members has made the last five years truly remarkable. Check out this article to see what HGG Advances has in store: ashg.org/publications-n… #ASHG #GeneticsDiscoveries

📣New from Kaixiong Ye & co! 📄A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GRP12 loci bit.ly/3HlYC99

Attending #ESHG2025? Be sure to say hi to Associate Editor Mike Innes! Tell him about your research & see if your work would be a good fit for @hggadvances!

📣New from Charnysh et al! 📄Multidisciplinary stakeholder-informed identification of key characteristics for implementation of workplace genetic testing 👉tinyurl.com/bdfrjsc6

📣New from Samantha Klasfeld -- open to work & co! 📄Common genetic modifiers influence #cardiomyopathy susceptibility among the carriers of rare pathogenic variants 👉tinyurl.com/2rsbzphf

What happens when you leverage the All of Us Research Program to study previously identified pathogenic germline variants & their relationship to cancer occurrence? Adam Bates & Matthew H Bailey, PhD, are breaking it down in the ASHG June Journal Club! ➡️ learning.ashg.org/products/cance…

Exploring the interplay of rare pathogenic variants and common genetic modifiers of cardiomyopathy, Human Genetics and Genomics Advances' latest study carefully assesses the benefits provided by variant effect predictions: cell.com/hgg-advances/f… #ASHG #HumanGenetics