Today we report a synthetic biology approach for specifically ablating cancer cells. RASER (Rewiring Aberrant Signaling to Effector Release) uses synthetic proteins to redirect cancer-driving signals to cell death. Details at Science: science.sciencemag.org/content/364/64… … #synbio

Congratulations to Hokyung Kay Chung, PhD, from the Kaechlab (Sue Kaech) Kaech Lab at Salk! She was recently named a Damon Runyon Cancer Research Foundation Fellow. Her aim is to create enhanced T cells that will infiltrate tumors and kill cancer cells. bit.ly/2YmcyYW

So happy for you Kay!! Can’t wait to watch you soar🤩

Also out today from the Michael Lin, MD PhD 🧬 lab, a Review on how proteases have been used for sensing and protein control in cell biology. nature.com/articles/s4159… free readcube rdcu.be/b5Ayp

For our second Nature Methods paper today, we wrote a review on the use of proteases to sense and control protein activities in living cells. We present how proteases, especially sequence-specific viral proteaes, are versatile tools for synthetic biochemistry. 💪H.Kay Chung

In Journal of Experimental Medicine, H.Kay Chung, @_Bryan_McD and Kaechlab (Sue Kaech) discuss the architectural design of CD8+ T cell responses during acute and chronic viral infection, incl. the parallelism of the differentiation pathways and heterogeneity of the resultant T cell states bit.ly/31bijZ2

Happy 20th Anniversary Kaech lab!! Cheers to an amazing group of scientists who are also a lot of fun!! ⁦Salk Institute⁩