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Delighted to share the first paper from Hannah Smith's PhD project. Out today in Clinical Epigenetics, she looked at protein EpiScores in relation to cognitive ability/decline, brain MRI and incident dementia outcomes across Generation Scotland and The Lothian Birth Cohorts rdcu.be/dCsvk

Marginal linear regression gives >11k EWAS hits for BMI. Joint and conditional BayesR gives 27! Methods matter in this pre-print from Hannah Smith. medrxiv.org/content/10.110… Metabolic EpiScores also translate across ancestries and assoc with brain health.

I’m grateful to have had the opportunity to present a poster on part of my PhD project at the Clinical Epigenetics conference in Warsaw, Poland this week.

One Health Genomics Edinburgh brings together The University of Edinburgh genomics researchers working across humans, animals, plants and ecosystems for sustainable planetary health. Watch the video below to find out more: #onehealth #genomics #edinburgh #planetaryhealth

The #Generationscotland cohort study (genscot.ed.ac.uk) is expanding, read the full plans in this newly published cohort profile: bit.ly/4cfSrOw Generation Scotland Institute of Genetics and Cancer Centre for Genomic and Experimental Medicine

Delighted to see @RobertHillary's protein vQTL + GxE paper using data from UK Biobank published in Nature Communications. nature.com/articles/s4146…

Danni Gadd's final PhD paper now out in Clinical Epigenetics. She previously showed that the protein GDF15 has incident assocs with 11 diseases in UK Biobank. Now she explores DNAm contributions to GDF15 (N~17,000 in Generation Scotland). …lepigeneticsjournal.biomedcentral.com/articles/10.11…

Movembering with many friends Psychology at Edinburgh for a fantastic local initiative. Please RT and consider donating. justgiving.com/page/edpsych-m…

“Lessons we learned from the Lothian Birth Cohorts of 1921 and 1936”: edin.ac/3YMksHV A new review of the main LBC findings on #brain and #cognitive #ageing (and much more!) by the founding and current Directors of the LBC1921 and LBC1936 Ian Deary and Simon Cox

New publication: DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts Generation Scotland Institute of Genetics and Cancer The Lothian Birth Cohorts Hannah MarioniGroup @RobertHillary Simon Cox Danni Gadd Elena Bernabeu @SarahEHarris99 Read more here: cell.com/ajhg/fulltext/…

New research from a team including IGC's MarioniGroup and Hannah highlights the relationship between DNA methylation and metabolic traits using Scottish and Singaporean cohorts. Read more here: institute-genetics-cancer.ed.ac.uk/research-highl…

A really interesting interview with Hannah about her research, career path and life outside work 👇

We're celebrating the International Day of Women and Girls in Science #February11 As #Womeninscience, we have the opportunity to shape research on #cognitive #ageing, influence policies that promote healthy ageing, and support future generations of women in #STEM. School of PPLS

New publication: Insights from a methylome-wide association study of antidepressant exposure ClinicalBrainScience Institute of Genetics and Cancer Ella Davyson Andrew McIntosh MarioniGroup Generation Scotland Mark James Adams Xueyi Shen The Lothian Birth Cohorts Mental Health at the University of Edinburgh Read more here: doi.org/10.1038/s41467…

Ola's paper "A blood- and brain-based EWAS of smoking" now published in Nature Communications nature.com/articles/s4146… Findings include: EPIC - TWIST - ONT comparisons, GWAS of DNAm smoking vs measured smoking, blood-brain DNAm comparisons, and EWAS + EpiScore...