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Distinct Molecular Trajectories Converge to Induce Naive Pluripotency - New research from José Silva & Lab out today in Cell Stem Cell cell.com/cell-stem-cell…

Stat3 induction reprograms through an early ICM state cell.com/cell-stem-cell… - nice demonstration that LIF/Stat3 signalling could be more about ICM identity than just epiblast.

So pleased to see our latest work published! This investigates how cellular identity change is instructed using reprogramming as a model system. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency cell.com/cell-stem-cell…

There is something familiar about the cover of Cell Stem Cell this month. cell.com/cell-stem-cell… @Hstuart21 Tim Lohoff Mariana R. P. Alves (she/her/ela/a) Alex Radzisheuskaya Elsa Sousa Reik Lab Cambridge Stem Cell Institute Cell Stem Cell marlin-prod.literatumonline.com/cms/attachment…

Really enjoyed writing about the connection between #science 🔬🧬🧪 and #art ✍️🖌️🎨 Thank you FocalPlane for giving me the opportunity to think outside of the scientific box! Happy #fluorescencefriday ! #biology #sciart #sciart #scicomm #microscopy #confocal

Really excited to share our paper on Nature Genetics about the impact of mitochondrial metabolism on nuclear DNA methylation. Thanks to European Research Council (ERC) ,Armenise Harvard Foundation, @Telethonitalia, Università di Padova for the amazing support. go.nature.com/39CU7Ur

What secrets does the amphibian #brain hold? We used single-nucleus sequencing @10xgenomics in #axolotl to find out! Exciting collaboration with Ashley Maynard, Tomás Gomes (@tomsgoms.bsky.social), Jonas (josch1@bsky), Gray Camp, Elly Tanaka and Treutlein lab! biorxiv.org/content/10.110… 🧵👇 1/19

I am full of joy to see our paper exploring the axolotl telencephalon published in Science Magazine today. What an honor to work together with such a dream team: Ashley Maynard, Tomás Gomes (@tomsgoms.bsky.social), Jonas (josch1@bsky), Gray Camp, Elly Tanaka and Treutlein lab!!!

3D ECM-rich environment sustains the identity of naive human iPSCs dlvr.it/SdhzXp

We are really excited our work is finally out Cell Stem Cell! Have a read if you want to know more about the supportive role of ECM on human naive pluripotency. Congrats to Elisa Cesare Urciuolo_Lab @Hstuart21 for the amazing work 👏

Amazing science, people and location. Thanks Novo Nordisk Foundation Science Cluster for the opportunity to share our recent work

New from Teresa Krammer, @Hstuart21 & co Organisers organise in organoids. But how? BMP signaling & physical sorting is responsible for self-organisation of FoxA2 expressing floorplate in neural tube organoids derived clonally from ES cells in vitro biorxiv.org/content/10.110…

I find so eternally alluring this developmental biology question of ‘who organises the organisers?’. Check out this beautiful and relevant new preprint of work spearheaded by Teresa Katharina Krammer, @Hstuart21, Elena Gromberg and others. Congratulations! biorxiv.org/content/10.110…

Have you ever wondered who organizes the organizer? Excited to share our latest discoveries about how a global application of retinoic acid (RA) can induce polarized neural tube organoids (NTOs). For more details, check out our pre-print below: biorxiv.org/content/10.110… 1/6

📢 It is with joy and humbleness that I share our first contribution to Huntington Disease(HD) research, out in Nature Communications. We identified genes with therapeutic potential against HD using pluripotent cells. 1/11 shorturl.at/dvEH8 #HuntingtonsDisease #stemcells

It is out 🧧! Huanhuan Li et al report on the generation of mouse cells with molecular and functional properties of embryo morula cells. jiekai chen MingyueGuo郭明岳 Man Zhang Mingwei Min Hannah Stuart Lawrence Bates oliviachang eunice_wu cell.com/developmental-…

I am very excited to share our latest manuscript on the axolotl nervous system. We established the use of adeno-associated viruses (AAVs) to perform circuit tracing in the axolotl brain and retina: doi.org/10.1101/2024.0… with Elly Tanaka @IMPVienna

I am beyond excited and happy to share that our work is finally out in Developmental Cell as of today🥹🥳 “Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition” sciencedirect.com/science/articl…

From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum biorxiv.org/cgi/content/sh… #biorxiv_cellbio

So happy to finally share for the first time how to obtain neural organoids from human naïve pluripotent stem cells! Thanks to the huge effort of Cecilia Elisa Cesare Hannah Stuart and all the contributors 🥳