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Pretty exciting work !

Wish i could take notes this neat !

Amazing stuff ! actu.epfl.ch/news/epfl-scie…

Exciting new chem. bio. tool to induce prot acetylation. - FKBP12(F36V) to tag prot of interest and recruit it to the KAT P300/CBP using a bi-functional molecule. - Hist. H3.3, p65/RELA and p53 were used as POC. Great work with a very thorough validation ! biorxiv.org/content/10.110…

Supplementary materials x.com/electricianvid…

What a data ! Gonna need some time to digest ... nature.com/articles/s4155…

Excellent review (and reality check) from @VeningaVivien and Emile Voest. "Tumor Organoids: Opportunities and Challenges to Guide Precision Medicine" cell.com/cancer-cell/fu…

Great job today Michelle - you definitely generated a lot of discussion around the big ideas you presented! Food for thought: today, when asked to draw a scientist only 28% of children will draw a female, that is up from 0.6% in the original study between 1966-1977

I feel personally attacked

Scotland's forest cover is nearly back to where it was 1000 years ago. Centuries of deforestation meant only 4-5% of its land was forested by 1750. But it's coming back, and closing in on 20%. From our @OurWorldinData work on forests and deforestation: ourworldindata.org/deforestation#…

Targeted protein degradation is one of the big ideas in biotech that doesn't get a lot of attention. Listen to Nello Mainolfi discuss on the latest episode of The Long Run. Kymera Therapeutics timmermanreport.com/2021/12/target…

Fantastic work on how extrachromosomal DNA cluster to form cooperative transcription hubs. Also reveals a new class potential targets for oncology, proteins involved in ecDNA hubs tethering and transactivation. nature.com/articles/s4158…

This type of control is part of what makes this field so exciting !

TPD used to uncover novel biology and therap. opportunities Using a nvl PROTAC degrader of SWI/SNF ATPase components to show that physical chromatin accessibility can be modulated and used as a novel therap. strategy in cancer treatment (prostat cancer) nature.com/articles/s4158…

The 2022 new update to the classical review Great read cancerdiscovery.aacrjournals.org/content/12/1/3…

Alphafold structure prediction with an intuitive interface. Finally.... These kinds of easy-to-use apps will be huge for biologists who don't have a computational background.

Best way to nerd on gene names !

The Wolf Foundation awarded Cravatt the prize for “developing activity-based protein profiling, which has emerged as a powerful and widely used chemical proteomic strategy to characterize enzyme function in native biological systems.” scripps.edu/news-and-event… Wolf Prize

If you are a PhD student or a postdoc at a Ukrainian university/institute on a topic related to structural biology and you would be interested in doing an internship in my lab at the University of Sussex (for ~up to 6 months or more if possible), please get in touch with me.

Interesting analysis. It's good to see that in oncology, where there are unfortunately still too many unmet medical needs, the ecosystem still favours and rewards, going after challenging targets with innovative therapies. nature.com/articles/d4157…