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JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms nature.com/articles/s4146…

How the electrocardiogram can identify previously undiagnosed structural heart disease with A.I. alone, better than cardiologists with A.I. support nature Pierre Elias, MD Timothy Poterucha nature.com/articles/s4158…

Delighted to collaborate on this study led by Jie Liu Kelly Bolton MD PhD describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy nature.com/articles/s4158… Nature Genetics

Clonal haematopoiesis to clonal cytopenias: unravelling disease evolut... sciencedirect.com/science/articl… The Lancet Haematology Kristina Kirschner Yael Kusne Catherine Cargo #CH #CCUS #Agerelated #Contextrelevant Mayo Clinic Comprehensive Cancer Center Mayo Clinic

Prednisone is recommended for the initial treatment of pulmonary sarcoidosis, but side effects are common. Methotrexate might offer an alternative to prednisone as first-line treatment. Research findings from the PREDMETH trial are summarized in a new Quick Take video.

1/6 - Lancée en 2003, la UK Biobank est l’un des plus grands et plus utiles investissements pour la recherche en santé publique, avec le plus large recueil de données biologiques et médicales au monde: 500’000 Britanniques y participe volontairement. bbc.com/news/articles/…

Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss nejm.org/doi/full/10.10…

Rheumatologic and autoimmune features of inborn errors of immunity: Implications for diagnosis and management  rupress.org/jhi/article/1/…

Analysis of whole-exome seq data from MyCode & BioMe biobanks investigated assoc between UBA1 VAF and VEXAS disease manif. Results showed ↑VAF resulted in more severe disease & higher penetrance, while ↓VAF had incomplete penetrance & milder disease A&R doi.org/10.1002/art.43…

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome Congrats Paul Breillat Benjamin Terrier Kosmider olivier ashpublications.org/blood/article-…

The Stars Align: The Incredible Discovery Story of VEXAS jrheum.org/content/jrheum…

EBV induces CNS homing of B cells attracting inflammatory T cell nature.com/articles/s4158…

For anyone interested in #VEXAS check out the 2nd international workshop happening Sept NYU Langone Health in NYC. Peter Grayson Bhavisha Patel Siniša Savić Sophie Georgin-Lavialle Mikkael A. Sekeres MD, MS Thibault Comont, MD Benjamin Terrier highmarksce.com/nyumc/index.cf…

NEW! ACR has published guidance statements as a resource for clinicians managing patients with suspected/confirmed VEXAS. These guidance statements offer practical advice on several key topics & provide considerations for management of the disease. VIEW → acr.tw/4liZrhh

novartis.com/news/media-rel…

Mycoplasma pneumonia infection may seldom lead to cold agglutinin syndrome; learn more about this association by reading @Kev_chevalier et al.'s recent paper on a French multicentre observational study doi.org/10.1002/ajh.70… #hematology

Original Article: A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline (FLUID trial) nej.md/45SaEBs #CriticalCare