We developed (scG2P) for targeted co-capture of DNA and mRNA with Mission Bio! - Dan Landau NY Genome Center bioRxiv Dennis J Yuan Ariel Swett oncodaily.com/blog/72544.html #Cancer #MolecularBiology #GenomeMapping #OncoDaily #Oncology

We are very happy to share our preprint (D. Lindenhofer et al.) of a high-throughput targeted scDNA-scRNA-seq (SDR-seq) method. Impactful for any application with a need to associate coding and non-coding variants to gene expression in tissue samples and cell culture systems.

Our paper exploring the effect of chromatin on prime editing and diverse pegRNA designs was published today! 👨‍💻🧬🎉 rdcu.be/dLu0f pridict.it UZH Science Nature Biotechnology Gerald Schwank Krauthammer Lab Bas van Steensel lab 🧵

I'm excited to share our latest work, out today in nature Grateful to work with amazing co-leads Mathys Lab Carles Boix , and always grateful for @DrLiHueiTsai 's mentorship! nature.com/articles/s4158…

Our commentary (with Alex Sasse @LXandR_ and Maria Chikina Maria Chikina ) on past and future of sequence-to-function deep genomics models is online Nature Methods : nature.com/articles/s4159… Along with many thoughtful Comment Articles online today: nature.com/nmeth/articles…

Excited to share my PhD work in the lab of @larsplus Centre for Genomic Regulation (CRG). We screened the activity of synthetic enhancers throughout myeloid differentiation. Combinations of activating TFs frequently neutralized each other or gained repression twtr.to/wiWIZ (1/n)

Have you ever wondered about how the genomic position of regulatory elements impact their functional output? Check out our latest pre-print from the @bvanssteensellab. biorxiv.org/content/10.110…

Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rather than diversification of the proteome Nature Genetics Yang I Li nature.com/articles/s4158…

Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to publish this review in Molecular Cell. We hope this will be a useful resource for the community. Hailing Shi Shuchen Luo Xiao Wang

Excited to share my lastPhD publication! We discovered non-inherited mutational patterns in schizophrenia occurring before birth. Huge collaborative effort w/ Vladimir Seplyarskiy Attila Jones science.org/doi/10.1126/sc…

Flexible differential expression analyses have always been neat in CZ #CellxGene. Now they’re next level! Quickly perform DE analysis across our entire data corpus. For ex: leveraging >125 relevant datasets to compare astrocytes with/without Alzheimer’s📷 bit.ly/4eDt9uU

Several excellent Human Cell Atlas papers in @nature this week. Highlights for me: 1. The integrated transcriptomic cell atlas of human neural #organoids, ZhiSong He 何志嵩 Treutlein lab Fabian Theis Gray Camp Sergiu P. Pasca Giorgia Quadrato & colleagues nature.com/articles/s4158…

Understanding the molecular diversity of synapses — a Review by Marc van Oostrum & Erin M. Schuman go.nature.com/3ZKmRVx Marc van Oostrum Erin schuman

Now Online: Modelling human brain development and disease with organoids go.nature.com/41uwWXO

How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (Han Yang), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s4158…. 1/12

Excited to be part of this amazing HAR project! 🎉 Congrats to the whole team! 🚀

A machine learning model for prime editing efficiency prediction takes into account chromatin context go.nature.com/3VQNmq9 rdcu.be/em3Yi

Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment: Cell cell.com/cell/fulltext/… Thrilled to see this transformative paper published- and so sad that its NIH funds are frozen!

Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6

Evolution of splicing model architectures go.nature.com/3I7QBoS Figure from our recent Review: From computational models of the splicing code to regulatory mechanisms and therapeutic implications (free to read here: rdcu.be/dVNV4)