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In our latest preprint, we used SuFEx chemistry on solid phase for a quick and easy library synthesis of HDACis: doi.org/10.26434/chemr… This was a fun project started by Michael Bæk and developed by Tobias Nørby Hansen and I, with great help from Erasmus student Linda Grlas! 1/8

The final version of our work is out now in JACS Au - it's open acess so give it a read to see how we discovered a simple substitution pattern to selectively inhibit HDAC6 and 11 with small molecules 🧪 pubs.acs.org/doi/full/10.10…

Inhibitors of histone deacetylases (#HDACs) have longer and longer on-target residence times, which may help future clinical applications. How is this achieved? Check out our new #OpenAccess Perspective JACS Au, with Yasir S. Raouf, to know more! 👇🏻 pubs.acs.org/doi/full/10.10…

New preprint ChemRxiv on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis EPFL Chemistry. Daniela Danková, Alexander L. Nielsen, Carlos Moreno-Yruela, Tobias Nørby Hansen, UCPH Healthscience We thank European Research Council (ERC), Novo Nordisk Foundation, DK Frie Forsk.fond for 💶 chemrxiv.org/engage/chemrxi…

We have an exciting PhD position available UCPH Healthscience. Together with researchers Scripps Research, we will investigate bacterial communication within the gut microbiome for potential health benefits, using chemical tools. Deadline 9 February, see 👇 candidate.hr-manager.net/ApplicationIni…