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This esophageal squamous cell carcinoma shows densely keratinized brightly eosinophilic cells.#umiamipath

Updated CAP Breast Cancer Biomarker Template March 19, 2025 In this update, Score 0 is separated in two groups: those with no staining and those with minimal staining (10% or less) The second group, with minimal staining, is eligible for treatment with trastuzumab-deruxtecan in

This is directed at the authors, editors, and administrators of the WHO Blue Books: 1️⃣ If a chapter relies on genetic testing unavailable to >80% of the world, it serves no one but those who already know the disease. Rewrite it. 2️⃣ If you plan to change nomenclature, ask: Does

Diagnostic pitfall in the liver. An oncocytic tumor in the liver, thinking HCC? Nah.. Turned out to be metastatic chromophobe carcinoma (was also CK7 positive). #Pathtwitter #Medtwitter #Pathresidents

Case of Matrix-Producing Metaplastic Carcinoma 🔬 Historically a subtype of metaplastic carcinomas with mesenchymal elements, matrix-producing metaplastic carcinoma shows abrupt transition of epithelial cells to chondroid/osteoid matrix. #PathX #PathTwitter #breastpath

Colonic malakoplakia, rare but real. Uncommon in the GI tract, but good to keep on the radar PMID: 32301754 #Pathology #MedTwitter CooperPathology

Interesting pattern of extensive fat necrosis in a mature ovarian teratoma with only focal ectodermal and endodermal elements (latter not shown). The whole tumor looked like this, with extensive foreign body cell reaction and histiocytic inflammation. #PathTwitter #gynpath

Glomeruloid forms in the prostate: - Pathognomonic of prostatic adenocarcinoma - Considered a type of Gleason pattern 4 WSI: pathlibrary.com/slidebox/?case…

Breast Histologic Variants of Invasive Lobular Carcinoma (ILC) -Many of these variants coexists and could be difficult to separate one from the other New variants (WHO 6th edition) -ILC with extracellular mucin -ILC with solid papillary growth Dr. Sahin #USCAP25 #pathology

Breast-Invasive lobular carcinoma Challenges in diagnosis Alveolar variant of ILC can mimic LCIS, important to run IHC (p63, SMMHC) to confirm diagnosis Dr. Sahin #USCAP25 #pathology #PathX

CAP members, elevate your pathology leadership skills at the CAP Engaged Leadership Academy! Build skills to make your voice heard and advance the specialty, June 28-29 in Northfield, Illinois. Limited space—register now! #Pathology #Pathologists #Leadership CAPathologists

Distant metastasis-Invasive Lobular Carcinoma Often presents as small and diffuse infiltrates rather than large discrete tumors Dr. Sahin #USCAP25 #pathology #PathX

Techniques to reduce positive margins in Breast Conserving Surgery in ILC -Use of shave margins is associated with 60% reduction in positive margin rate -Oncoplastic surgery is also associated with 60% reduction in positive margin rate in ILC Dr. Mukhtar #USCAP25 #pathology

Case of Fibroadenoma with Myxoid Stroma 🔬 Hypocellular myxoid stroma can give fibroadenoma a strikingly distinctive appearance and can be seen both in sporadically or in association with Carney complex. #PathX #PathTwitter #breastpath

Been silent for a while, so here's one of my favorite things to talk about. What is your diagnosis? UDH? ADH? DCIS? #breastpath #PathTwitter WashU Medicine Pathology & Immunology WashU Medicine Pathology & Immunology Education

Lymphovascular invasion (LVI) in Merkel cell carcinoma. Size of primary tumor does not matter. Even small primary cutaneous Merkel cell carcinomas can have LVI. #RealLifeDermpath #pathology #dermpath

You all are rockstars! ⭐️ The answer was periductal stromal tumor. These tumors show biphasic fibroepithelial elements typically devoid of leaf-like frond formation—think of these as the pericanicular pattern of phyllodes tumor. #PathX #PathTwitter #breastpath

(2/2) Considering that “TROP2 was initially identified in 1981 based on its expression on human trophoblast cells in a study investigating choriocarcinoma cell lines” it seemed logical to evaluate expression in choriocarcinoma. IHC screening could identify high expressors

Ready for love at first slice…of tissue? Join Virtual Pathology Student Interest Group and the CAP on June 1 at Noon CT to find your subspecialty match. Whether you're into the heart (cardio), brain (neuro), or skin (derm), there's a #PathologyMatch waiting for you! Sign up today: brnw.ch/21wSZn8