My overview talk from Single Cell Genomics Day 2024, covering our favorite new technologies and computational methods for the single-cell/spatial field, is now online at youtube.com/watch?v=eQ7wzm… (thanks @ATCCagan for the live illustration!)

“The next big game-changing revolution is in biology.” Cannot agree more! We are at a pivotal moment where vast amounts of biological data are being generated, and large-scale models are increasingly accessible for analyzing omics and sequences. There’s truly no better time

Inspired by Lior Pachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics #Bioinformatics

It's #FluorescentFriday! What happens in the brain during normal aging? While most neurons will not shrink, they will lose synapses, the connections between different neurons, which can affect learning and memory. But how do we take these images from primates? (1/5)

Can AI rewrite our human genome? ⌨️🧬 Today, we announce the successful editing of DNA in human cells with gene editors fully designed with AI. Not only that, we've decided to freely release the molecules under the Profluent OpenCRISPR initiative. Lots to unpack👇

Super fun and filling joint Moe Mahjoub 🇨🇦🍁 and Miner Lab soirée to wish early goodbyes to Hani Suleiman Hani Suleiman, MD, PhD and Ewa Langner Ewa Langner as they prepare to move to UTSW Nephrology And farewell to George Jarad (St. George, UT) as well! @WUNephrology

The first prime editing clinical trial has been cleared by U.S. FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to Prime Medicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.

Pls help! #PathTwitter #BreastPath Any thoughts on what tumor it is? Myxoma, Sarcoma, or else? From my wife, resected ~3 wk ago 42 y/o female Fast-growing left breast mass 6 x 5 cm➡️10 x 8 cm in <1 month HE staining: mass center. Any marker to stain? Thanks!!!🙏🙏🙏🙏🙏

An orangutan in Sumatra surprised scientists when he was seen treating an open wound on his cheek with a poultice made from a medicinal plant go.nature.com/3UrXtjk

Our new paper on “synpoptosis” circuits, led by the amazing Shiyu Xia, is now out: sciencedirect.com/science/articl… (1/3)

People with 2 copies of APOE4 were known to have a high risk of #Alzheimers. Today that changed to nearly 100% full penetrance NATURE.med nature.com/articles/s4159…

Excited to share our Seurat update supporting VisiumHD data from 10x Genomics. We explore and validate the ability of HD to map the spatial localization of individual cell types: satijalab.org/seurat/article…

Dean Perlmutter, MD, Test Account & Jeffrey H. Miner have been elected to AAAS one of the most distinct honors in the scientific community. The AAAS is an international non-profit organization dedicated to advancing science around the world. Learn more> l8r.it/WY7i

Alyssa is the first patient to receive a base edited therapeutic (triply base edited CAR-T cells that cleared her T-cell leukemia), doing well now more than two years post-treatment thanks to the efforts of Waseem Qasim’s team and GOSH.

New paper is out! If you're interested in doing expansion microscopy of #kidney tissue, come give it a try 🔬 Happy #FluorescenceFriday all! 🌈

Hifiasm is able to combine HiFi and ultra-long reads for high-quality assembly. It often assembles multiple human chromosomes in T2T and has been deployed by HPRC and other groups. If you wonder how that works in detail, see Haoyu's recent paper at rdcu.be/dHxG3

A 96-Well Polyacrylamide Gel for Electrophoresis and Western Blotting biorxiv.org/content/10.110…

Very proud to share our work on histopathological based analysis of ST kidney data. So grateful to my wonderfull mentor Benjamin D. Humphreys @humphreyslab !!! ajp.amjpathol.org/article/S0002-…

Very excited to share our latest work on #singlecell epigenetics for time-course mouse acute kidney injury and human #AKI now available Science Advances Thanks tons for my postdoc days mentor Ben Humphreys science.org/doi/10.1126/sc…

Excited to join the fantastic #AGBTPH meeting in Denver for the first time! Visit our poster #109 to see how we used single-cell and spatial transcriptomics to identify novel pathways linked to kidney disease. Ben Humphreys