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Few weeks ago installed our new MicroED/3DED instrument,Glacious 2, we are collecting data on new protein crystals that diffracted at 2.7 Å at the synchrotron,now pushing below2 Å with MicroED. Very happy and excited! #MicroED Movingwhat Hongyi Xu CMM@UQ Kobe Lab Thermo Fisher

Check out our latest work done Ramaciotti Centre for Cryo EM. 75kDa membrane protein PqqU-PQQ complex at 2 Angstrom resolution. Data again from our G1 krios with K3 and BioQuantum filter.

New research from the Grinter lab just published in FEBS Letters. doi.org/10.1002/1873-3… Daniel Fox solved the crystal structure of hemoglobin (from my blood) in complex with two copies of a nanobody. The crystal is super funky, with one Nb almost totally disordered. 1/3

Last week's release of #SerialEM beta testing introduces "Multiple Grid Ops", an interface to auto acquire grid maps, square maps, and final data from multiple grids in a row using Microscopy & Spectroscopy /JEOL USA autoloaders.

Seminar alert! ⏰ The Australian Research Council CCeMMP seminar series welcomes Ali Punjani (CEO, Structura Biotechnology Inc, Toronto, Canada) as our July speaker. Please join us & register here: ccemmp.org/events/ccemmp-… Structura Biotechnology Ali Punjani

Excited to share the 1st preprint from Shabih Shakeel lab WEHI (Walter and Eliza Hall Institute) on oncoprotein MORC2 that is now available on bioRxiv! Here’s a thread on our main findings on how  MORC2 phosphorylation influences DNA compaction and its implications in cancer🔬📜 biorxiv.org/content/10.110…

In situ single-particle cryo-EM is picking up steam. Mind-blowing work!!!🤯

Working on #cryoEM for membrane proteins? This new #CryoSPARC case study covers end to end advanced processing of a 73 kDa inactive state GPCR, including challenges and pitfalls, detailed figures and final maps. Read in full here: guide.cryosparc.com/processing-dat…

Check out these fantastic 100keV results from Thermos's Falcon C detector when imaged using a FEG source.

We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s4158… 🧵

Thrilled to see our work out in nature on the #cryoem structure of LYCHOS! A monumental effort from co-first author Charles Bayly-Jones, the @Dr_Ellisdon Lab, the Dr Michelle L Halls Lab from MIPS DDB, Hari Venugopal from Ramaciotti Centre for Cryo EM. nature.com/articles/s4158…

Excited to share our first foray in ML-guided protein design. With the Gavin Knott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. biorxiv.org/content/10.110…, biorxiv.org/content/10.110…

We are excited to share pre-prints describing a successful foray into ML-driven protein design. With Rhys Grinter we designed proteins to potently inhibit CRISPR-Cas13 (doi.org/10.1101/2024.1…) or block heme piracy by pathogenic E. coli (doi.org/10.1101/2024.1…):

High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub–200-keV direct electron detector | Science Advances science.org/doi/10.1126/sc…

High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with the Alpine camera, a sub–200-keV direct electron detector from Gatan. Read about it today: ow.ly/4HiB50UKqfk #cryoEM #DirectDetection

Resolving native GABAA receptor structures from the human brain | Nature doi.org/10.1038/s41586…

Do you want to know if you have what it takes to work in a large centralised EM platform, short stint just to see ! come and join us ⁦Bio21 Institute⁩ ⁦University of Melbourne⁩ : Research Fellow in Electron Cryo Microscopy (Part-time) : jobs.unimelb.edu.au/en/job/919320/…

Another awesome collaboration with Rhys Grinter lab. Check out our latest high resolution cryo-EM work, ~70kDa membrane protein. Imaging done at Ramaciotti Centre for Cryo EM