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70% of patients with treatment resistant #depression who didn’t respond to aripiprazole responded to pramipexole in this uncontrolled study: pubmed.ncbi.nlm.nih.gov/40163774 It is in line with my experience, and with trial of pramipexole in patients who failed ECT.

To not treat moderate to severe depression, when there is a clear evidence base and NICE Guidance, is a dereliction of care. Happily, we’re not living in the pre-effective mental health treatments era. Just as we are lucky not to be living in the pre-antibiotics or vaccines era.

Preop plasma concentrations of p-tau181, p-tau231, and p-tau217 predicted the occurrence & severity of postop #delirium in older adults having laparoscopic surgery P-tau231 had the highest predictive value 🔗 doi.org/10.1093/gerona…

Full interview of Otto Kernberg... 00:00 Fleeing Nazi Austria 05:51 Early Influences 22:56 Borderline Level of Functioning and Primitive Defenses 31:02 Sexual Life in Borderline and Narcissistic Personality 45:09 Transference-Focused Psychotherapy and Reflective Function

Eileen Joyce again. Strong evidence that clozapine is effective in treatment of psychosis in Parkinson’s and doesn’t worsen motor or cognitive functioning.

Clinics offering unproven, unapproved #stemcell treatments have quadrupled in 5 years — & so has the litigation. False adverts, fraud, and patient harm are rampant. Is litigation our last line of defense against medical #grifters? How can we encourage patients to seek justice?

Research estimates that at least 50% of people with Parkinson’s disease will experience a form of depression. However, this PD symptom is often overlooked & undertreated! Treating depression is one of the most significant ways to decrease disability and improve quality of life.

Why? Is someone blocking food from getting in and deliberately starving them?

When we get to the #AssistedDying debate, I hope we can •agree no side has a monopoly on compassion •accept that individual choice is always in balance with social values •ask if 4000 deaths/yr is acceptable •consider the profound change to the doctor-patient relationship.

Dr Katie Cairns Jess Walker David Oliver (also on Blue Sky) Ash Paul Burnt Toast Richard Fitzgerald 💙 🦀 RC of Pathologists Bernie Croal Michael Osborn Jo Martin 💙 Dr Suzy Lishman CBE 👩🏻‍🔬 PathSocPresident RCPath Trainees' Advisory Committee BSH - Haematology The Leng review Professor Stephen Powis Professor Chris Whitty Jeanette Dickson Kath Halliday Stephen Harden Tom Roques The Royal College of Radiologists Robin Proctor Margaret McCartney Abi Rimmer The BMJ NHS England Minna Johansson Richard Lehman Royal College of General Practitioners Daniel Ross AJR Michigan Radiology Matt Davenport The frequency of incidental imaging findings.... bmj.com/content/361/bm…

Tens of thousands of migrant nurses are ready to quit working in the UK due to hostile immigration rules and poor pay, according to a new report. A survey of 3,000 nurses by the Royal College of Nursing revealed that 42% are planning to leave. nursingtimes.net/workforce/immi…

Always encouraging when your research resonates with researchers you admire. Please read this excellent commentary on our paper - ‘Beyond a syndrome: a mechanism for #depression in #Parkinson’s disease.’ academic.oup.com/brain/advance-…

“A sane country does not wage war against civilians, does not kill babies as a pastime, and does not engage in mass population displacement,” Yair Golan, the former deputy chief of staff of the Israeli army

We are going to lose an entire generation of scientists. NSF, one of the largest federal funder of STEM education has seen an 80% reduction in funding, including support for trainees, so far this year. “You can’t have science without scientists”

“Enhanced ERK activity extends ketamine’s antidepressant effects by augmenting synaptic plasticity” by Lisa Monteggia et al. Science dx.doi.org/10.1126/scienc…

Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get this powerful therapy to more people go.nature.com/43hf4jQ

“According to UNICEF, 50,000 boys and girls have been killed or injured in just 20 months,” UNRWA’s Juliette Touma tells RTÉ. Civilians, including children, humanitarian and medical workers, first responders, and journalists, continue to be killed and injured in the Gaza

🧠 New paper out in BJPsych Bulletin: We surveyed psychiatry trainees across the UK— >40% are interested in #neuropsychiatry, but only 10% expect to get enough training. Trainees want: ✔️ More access ✔️ Neurology integration ✔️ Formal accreditation doi.org/10.1192/bjb.20…

🚨🍄 Major new preprint alert 🍄🚨 I think these will be important results. They are not going make me popular with my #psychedelic in-group, please do not shoot the messenger! The premise of this pre-registered meta analysis (osf.io/preprints/psya…) is that it is biased to