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Fantastic nature News Feature by anil oza- Why does heart disease affect so many young South Asians? Highlights our ambitious goals with OurHealth & others like MASALA Study. nature.com/articles/d4158… 💜 ourhealthstudy.org 💜 Sadiya Khan Alka Kanaya @NammiKan

>5000 Polygenic scores now available at PGSCatalog.org! As of today's release we've broken 5k PGS, indexing data from 673 unique publications. A big thank you to the authors submitting their data and our team in pursuit of #openscience, #FAIRdata, and reproducibility!

Our new study published in Nature Communications, led by Ghislain Rocheleau and team. Using TOPMed WGS data, estimate heritability of CAD is 34%. Ultra-rare variants with low LD score contribute ~50% of the heritability. Enrichment in several functional processes. nature.com/articles/s4146…

The catalog of all possible SNVs altering existing upORFs or creating new ones (via both canonical  and non canonical TIS) in human transcripts is available on the mobidetails platform ( mobidetails.iurc.montp.inserm.fr/MD/) @soukarieh_omar BORDEAUX POPULATION HEALTH Center University of Bordeaux

Probably the most important paper I will ever write link.springer.com/article/10.118… Stephen Burgess BMC Medicine

London -> Barcelona by train ✅ (surprisingly easy! 🚄) Just arrived for the 2024 Nextflow Summit, very excited to be delivering the keynote tonight on this mildly intimidating stage (tech tests ✔️, Segrada Familia ✔️ … we’re ready to roll)

Lipoprotein(a) is an independent predictor for long-term in-stent restenosis and should be considered in the evaluation of patients undergoing PCI. academic.oup.com/eurjpc/article… European Society of Cardiology Victor Aboyans Silvia Castelletti Francesco Perone Andrea Gallardo #cvprev

Great collaborative work spearheaded by Maddalena Ardissino Adam Butterworth showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events ahajournals.org/doi/10.1161/CI… Circulation: Genomic and Precision Medicine

The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway). New study shows even greater (10% ↓odds) for AAA.

2⃣Bridging genomics, transcriptomics, proteomics, and metabolomics In a rare combination of all 4 major omics layers, this study offers a great resource for dissecting the links between genetics, expression/slicing, molecular traits and disease risk 🔗nature.com/articles/s4158…

In patients with calcific aortic valve stenosis, lipoprotein(a) levels predict a higher risk of valvular and cardiovascular outcomes. #AHAJournals Hasanga Manikpurage Labo Dr Clavel Philippe Pibarot Benoit Arsenault ahajrnls.org/4iqZYxj

📣New from Zamani et al! 📄Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets 🫀🧬 👉bit.ly/43bMPBU