Published version of our paper on nnSVG - method to identify spatially variable genes - is now available from Nature Communications Nature Communications ! 🎉 nature.com/articles/s4146…

Updated version of our paper on the gene expression landscape of the human locus coeruleus (LC) is now available on bioRxiv 🎉 biorxiv.org/content/10.110…

So excited to see our manuscript in this special issue coupling spatial transcriptomics w/ immunofluorescence to quantify changes in spatial gene expression with respect to Alzheimer's disease pathology in post-mortem human brain tissue liebertpub.com/doi/10.1089/ge…

Thrilled at my FIRST blog post about #Alzheimers research.libd.org/rstatsclub/202… & BIG news about our paper officially published in GEN Biotechnology spatial-omics issue doi.org/10.1089/genbio… Huge Kudos to all coauthors, mentors, & supporters Lieber Institute BCMB Graduate Program at JHMI 10x Genomics🙌🙌

Ok, I did one too - not as creative as everyone else - presentations from me, @CerceoPage + Kristen R Maynard groups. We've got fun human 🧠 regions - habenula, septum, amygdala and 🔵, spatial multiomics and 🐭 in vivo imaging during attention - appropriate for Wed PM slot ;)

It's almost time for #SfN23, and our scientists are ready! Catch Kelsey Montgomery and her poster "Molecular mapping of the human habenula using single cell and spatial transcriptomics" on Saturday, and stop by our booth to learn more about the Lieber Institute!

Excited to present our work in Locus coreleus 🔵 at #SfN23 Come stop by at the poster PSTR041.14 on Saturday to know more! #BlueSpot #locuscoeruleus

It's #SfN23! Catch Research Associate Heena Divecha and her poster PSTR041.14 "Generation of spatial landscape of gene expression in the human locus coeruleus using spatially resolved transcriptomics and single nucleus RNA-sequencing" today!

It's #SfN23! Catch Annie Nguyen's poster session "Benchmarking spot-level deconvolution methods in the human dorsolateral prefrontal cortex using Visium Spatial Proteogenomics" this afternoon, and stop by our booth to learn more about the Institute!

All of our human brain poster are in today’s poster session, starting soon! #SfN23 Presenters @linasyoh Annie Bich Nguyen Heena Divecha and Maddie Valentine are all applying to neuro PhD programs this cycle!

Happy #SfN23! Catch Jorge Miranda Barrientos and his poster PSTR563.13 "Activity patterns of mouse prelimbic cortical neurons during the continuous performance test" on Wednesday afternoon! Plus, stop by our booth for fun giveaways.

Dr. Lukas Weber Lukas Weber will give a Statistical Genomics & Genetics seminar at Columbia Biostatistics Department ColumbiaPublicHealth this Wednesday at 3-4pm! Welcome to join us at columbiacuimc.zoom.us/j/4605723063 🤓

Some HUGE norepinephrine neurons in the human locus coeruleus, marked by tyrosine hydroxylase TH, 🟢). Image credit to Heena Divecha #FluorescenceFriday 🧠🔬💙

Also, I want to thank Heena Divecha Lukas Weber for leading our first paper profiling the human locus coeruleus using #snRNAseq and #spatial #transcriptomics published in eLife - the journal late last year! 🔗 elifesciences.org/reviewed-prepr…

And huge shout out and thank you to the many people who helped with generating prelim data for this award - MadhaviTippani Sang Ho (Sangho) Kwon Heena Divecha Aaron Salisbury Lukas Weber @CerceoPage Kristen R Maynard

New in Science Magazine: our work from Lieber Institute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

For #FluorescenceFriday - labeling norepinephrine neurons in the human locus coeruleus with tyrosine hydroxylase 🟢, and some Tau accumulation starting (there is no magenta circle emoji). Image credit to Heena Divecha 🔬👩‍🔬💙

Bringing my account back to life just in time for #FluorescenceFriday with a peek at our preliminary dive into the human LC🔵in AD. Glials & microvessels surrounding tangles - let the adventure begin into their -omics! Major credit to Heena Divecha for the perfect slice!

Division of Translational Neuroscience Lieber Institute will be at #SfN24! Presentations span mice, monkeys and humans from molecular to cellular through circuits and behavior. If you are interested in what we do, please stop by! Jason Rehg Michael Totty @R_Phillips_3rd Yufeng Du 杜御风