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Tom's amazing Nature Reviews Chemistry review is finally out!! Learn more about hidden #enzymology, unprecedented chemistry & new approaches for exploring microbial dark matter at #naturalproducts nature.com/articles/s4157…

Nice work by the Stanley-Wall lab: Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm pnas.org/content/116/27…

First time to achieve peptide ligation in water, offering a chemical perspective of chicken-and-egg problem for the origin of life nature.com/articles/s4158…

The long-awaited TransAtor paper is out in Nature Chemical Biology! TransAtor is a web application enabling de novo structural predictions of trans-AT PKS-derived polyketides. nature.com/articles/s4158…

Read Jörn‘s nature #behindthepaper on how we developed the TransATor, a web tool for de novo structure predictions of trans-AT polyketides & why you need it go.nature.com/2jL18eL

Natural products go RNA: The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation cell.com/cell-chemical-…

We have new, hypermodified peptides for you! Check out our aeronamide (from Microvirgula) & polygeonamide (from deep-rock metagenome🤘🎸) story at Nature Chemistry nature.com/articles/s4155… #RiPPs

🤔 could have submitted more

Who makes antibiotics and how do NRPS work? See the Grininger/Bode group performance for kids here: rz.uni-frankfurt.de/68128012/Kinde…

Finally... more than a module! Great NRPS work from the Schmeing lab: Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility science.sciencemag.org/content/366/64…

Luckily, despite severe jet lag, Helge’s given a clear, nice talk SIMB #NaturalProducts on NRPS engineering with a more efficient approach. Showing the advantages of artificial docking domains in splitting and reconstructing the megasynthetases

An awesome addition to polyketide biosynthesis. TE disguises itself as KS catalyzing branched polyketide formation. Read about Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A pubs.acs.org/doi/10.1021/ja…

Next round in "the many things that regulatory RNAs can do" - this time: controlling natural-product synthesis. Fantastic collaboration with the Bode lab (Bode Lab) published today in Nature Microbiology nature.com/articles/s4156…

The latest update for NRPS engineering, based on a evolutionary breakpoint within thiolation domains is out: doi.org/10.1101/2022.1…

With our newest preprint on engineering NRPS we succeeded in optimizing our first-of-its-kind biocombinatorial technology. Read more here: Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases biorxiv.org/content/10.110…

Finally! After a long journey our latest NRPS engineering story is out at science.org/doi/10.1126/sc… thanks to the hard work of several members from the @HelgeBode_lab

And here is another cool story about trans-AT PKS engineering in the same issue science.org/doi/10.1126/sc… from the Piel Lab. Congratulations!!

CRISPR now also available for Xenorhabdus and Photorhabdus for easy access to natural products and manipulation of their biosynthesis: Please see the paper from Alexander in Microbial Cell factories: rdcu.be/dDibN

Leonard has applied the XUT NRPS engineering technology to solve the biosynthesis of the potent antibiotic odilorhabdin in collaboration with the Rolf Müller lab at Antibiotikaforschung (inaktiv). See his paper in Angewandte Chemie: doi.org/10.1002/anie.2…

Happy to announce the first steps into NRPS/PKS engineering thanks to the work from Leonard and collaborations with the labs from Markus Kaiser and Michael Groll: Bioengineering of syrbactin megasynthetases for immunoproteasome inhib... sciencedirect.com/science/articl…