Jose Sandoval S, MD FACP ๐Ÿ‡จ๐Ÿ‡ด๐Ÿ‡จ๐Ÿ‡ด (@hemsandoval) 's Twitter Profile
Jose Sandoval S, MD FACP ๐Ÿ‡จ๐Ÿ‡ด๐Ÿ‡จ๐Ÿ‡ด

@hemsandoval

ID: 4067920889

calendar_today29-10-2015 13:06:16

6,6K Tweet

1,1K Followers

1,1K Following

Vincent Rajkumar (@vincentrk) 's Twitter Profile Photo

Just out in the New England Journal of Medicine! Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance NEJM nejm.org/doi/full/10.10โ€ฆ 5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and

Just out in the New England Journal of Medicine!

Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance <a href="/NEJM/">NEJM</a> nejm.org/doi/full/10.10โ€ฆ

5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS.  Lots of Tables and
Barbara Segarra (@barbarasegarra) 's Twitter Profile Photo

2nd Latino Cancer Patient Advocate Training Program. If you qualify(or know someone that does) apply by completing the form forms.gle/9YEQmwV9yh8Axnโ€ฆ

2nd Latino Cancer Patient Advocate Training Program. 
If you qualify(or know someone that does) apply by completing the form 

forms.gle/9YEQmwV9yh8Axnโ€ฆ
Kate Cwynarski (@cwynkate) 's Twitter Profile Photo

Outcome of pts w Mantle Cell Lymphoma after Failure of Anti-CD19 CAR-T Cell Therapy is partic poor: Descar-T Study โฆLysa Lymphomaโฉ Bispec Abs appear promising offering durable responses c.f to chemotherapy & targeted therapy โฆBlood Advancesโฉ ashpublications.org/bloodadvances/โ€ฆ

Federaciรณn Colombiana de Enfermedades Raras (@fecoer) 's Twitter Profile Photo

๐ŸšจAMPLIFIQUEMOS LA VOZ DE ANDRร‰S โ€“ ES #URGENTE SALVAR SU VIDA ๐ŸšจNUEVA EPS LE NIEGA SU MEDICAMENTO VITAL ๐Ÿ†˜ Andrรฉs Felipe Henao Muรฑoz, 27 aรฑos, Andrรฉs Felipe Henao Muรฑoz con enfermedad rara Inmunodeficiencia Comรบn Variable, hipertensiรณn pulmonar e insuficiencia cardรญaca. La NUEVA EPS le ha

Alex Rampotas (@arampotas) 's Twitter Profile Photo

Well done to Claire Roddie and team for this amazing work. Many take home messages from this work -Lymphodepletion is essential for CAR-T to work -Repeat doses don't seem to work here, but more work is needed HCC_UCLH ashpublications.org/blood/article-โ€ฆ

Toby Eyre (@tobyeyre82) 's Twitter Profile Photo

Hot off the press! Lewis et al. Wonderful to see this international investigator initiated academic RCT published open access in The Lancet today Fantastic UK+Nordic collaboration #MCL #Lymsm thelancet.com/journals/lanceโ€ฆ

Jose Sandoval S, MD FACP ๐Ÿ‡จ๐Ÿ‡ด๐Ÿ‡จ๐Ÿ‡ด (@hemsandoval) 's Twitter Profile Photo

This yearโ€™s #NobelPrize goes for the discovery of regulatory T cells (Tregs) and FOXP3. Absolutely vital discovery in the field of hematology, oncology, cellular therapy, rheumatology, neurologyโ€ฆall medicine! Immunology at its best!

Ajay Major, MD, MBA (@majorajay) 's Twitter Profile Photo

Ven/obinu outcomes CLL13/14 - 410 pts, 56% unfit CIRS>6 or GFR<70 - no diff PFS/OS by fitness - AEs not different in fit vs unfit - inferior PFS if <70% ven dose intensity (no diff OS) Would love to see this analysis in non-trial fit/unfit cohort. #lymsm ashpublications.org/blood/article/โ€ฆ

Ven/obinu outcomes CLL13/14
- 410 pts, 56% unfit CIRS&gt;6 or GFR&lt;70
- no diff PFS/OS by fitness
- AEs not different in fit vs unfit
- inferior PFS if &lt;70% ven dose intensity (no diff OS)
Would love to see this analysis in non-trial fit/unfit cohort. #lymsm ashpublications.org/blood/article/โ€ฆ
AmericanJournalofHematology (@ajhematology) 's Twitter Profile Photo

Acquired factor X deficiency, a rare complication of AL amyloidosis, affects ~4.4% of patients. FX activity improves with clone-directed therapy, with greater recovery in hemCR. HDM/SCT is associated with improvements but carries bleeding risks doi.org/10.1002/ajh.70โ€ฆ Andrew Staron

Acquired factor X deficiency, a rare complication of AL amyloidosis, affects ~4.4% of patients. 
FX activity improves with clone-directed therapy, with greater recovery in hemCR. HDM/SCT is associated with improvements but carries bleeding risks
doi.org/10.1002/ajh.70โ€ฆ <a href="/a_staron/">Andrew Staron</a>
Toby Eyre (@tobyeyre82) 's Twitter Profile Photo

โ–ถ๏ธReally important analysis of #pirtobrutinib resistance in R/R #CLL from BRUIN now online in Blood Journals Portfolio Genomic Determinants of Response and Resistance to Pirtobrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia ashpublications.org/blood/article/โ€ฆ

The Nobel Prize (@nobelprize) 's Twitter Profile Photo

BREAKING NEWS The Norwegian Nobel Committee has decided to award the 2025 #NobelPeacePrize to Maria Corina Machado for her tireless work promoting democratic rights for the people of Venezuela and for her struggle to achieve a just and peaceful transition from dictatorship to

BREAKING NEWS
The Norwegian Nobel Committee has decided to award the 2025 #NobelPeacePrize to Maria Corina Machado for her tireless work promoting democratic rights for the people of Venezuela and for her struggle to achieve a just and peaceful transition from dictatorship to
Oncology Brothers (@oncbrothers) 's Twitter Profile Photo

2 trials reinforce less is more with anti-platelet & DOACs: 1. AQUATIC (NEJM): Adding ASA to DOACs in chronic coronary syndrome = โ†‘ death + bleeding 2. ATISโ€‘NVAF (JAMA): Adding ASA to DOACs after stroke w/ concurrent Afib+ASCVD = no benefit + โฌ†๏ธ ๐Ÿฉธ #HemeTwitter #MedTwitter

2 trials reinforce less is more with anti-platelet &amp; DOACs:

1. AQUATIC (NEJM): Adding ASA to DOACs in chronic coronary syndrome = โ†‘ death + bleeding

2. ATISโ€‘NVAF (JAMA): Adding ASA to DOACs after stroke w/ concurrent Afib+ASCVD = no benefit + โฌ†๏ธ ๐Ÿฉธ

#HemeTwitter #MedTwitter
๐—ก๐—ถ๐—ต๐—ฎ๐—ฟ ๐——๐—ฒ๐˜€๐—ฎ๐—ถ MD, DM (@nihardesai89) 's Twitter Profile Photo

Site of action of hyperuricemic drugs in the purine metabolism pathway! The hydrogen peroxide produced as a byproduct of Rasburicase activity โžก๏ธ oxidative stress โžก๏ธ hemolysis if G6PD deficient! ๐Ÿ“ธ DOI: 10.1056/NEJMra23009

Site of action of hyperuricemic drugs in the purine metabolism pathway!

The hydrogen peroxide produced as a byproduct of Rasburicase activity โžก๏ธ oxidative stress โžก๏ธ hemolysis if G6PD deficient!

๐Ÿ“ธ DOI: 10.1056/NEJMra23009
๐—ก๐—ถ๐—ต๐—ฎ๐—ฟ ๐——๐—ฒ๐˜€๐—ฎ๐—ถ MD, DM (@nihardesai89) 's Twitter Profile Photo

Left: This is where it all started Right: This is where we are in 2025 ๐Ÿ’ช๐Ÿฝ This is what progress looks like! Trust science, trust the process ๐Ÿ™๐Ÿฝ Ref: 10.1056/NEJM194806032382301 Ref: 10.1056/NEJMoa2411680

Left: This is where it all started

Right: This is where we are in 2025 ๐Ÿ’ช๐Ÿฝ

This is what progress looks like!
Trust science, trust the process ๐Ÿ™๐Ÿฝ

Ref: 10.1056/NEJM194806032382301
Ref: 10.1056/NEJMoa2411680