Henning Plage (@henningplage) 's Twitter Profile
Henning Plage

@henningplage

Urologist| Charité University Hospital Berlin, Germany| Interested in Bladder Cancer

ID: 1704756346388725760

calendar_today21-09-2023 07:16:30

58 Tweet

25 Followers

66 Following

Tom Powles (@tompowles1) 's Twitter Profile Photo

The EMA has approved Enfortumab Vedotin and pembrolizumab for 1st line urothelial cancer. It supersedes 1st platinum based therapy as the new standard of care in Europe. astellas.com/en/news/29371?…

Tom Powles (@tompowles1) 's Twitter Profile Photo

urothelial cancer highlight #ESMO24 New ADC data (1st line DV/pembo, EGFR/HER3),TAR200 (pretzel) in MIBC (SUNRISE4), EV/pembro biomarkers (EV302), adjuvant (TOMBOLA) and neoadjuvant (VOLGA) ctDNA, updates on adjuvant pembro (AMBASSADOR), neoadjuvant chemo +/- durvalumab (NIAGRA)

Jason Brown (@jasonbrownmdphd) 's Twitter Profile Photo

Disitimab vedotin + Pembrolizumab in 1L treatment for mUC presented by Matt Galsky. Thrilled to have participated in this trial University Hospitals Case Comp Cancer Ctr 🎯 HER2 is important target even in HER2 low patient 🏆 75.0% ORR, 35% CR ➡️ DV + P vs DV randomization ongoing

Disitimab vedotin + Pembrolizumab in 1L treatment for mUC presented by <a href="/MattGalsky/">Matt Galsky</a>. Thrilled to have participated in this trial <a href="/UHhospitals/">University Hospitals</a> <a href="/caseccc/">Case Comp Cancer Ctr</a> 

🎯 HER2 is important target even in HER2 low patient

🏆 75.0% ORR, 35% CR

➡️ DV + P vs DV randomization ongoing
Enrique Grande (@drenriquegrande) 's Twitter Profile Photo

NIAGARA is the first randomized trial to demonstrate significant OS difference in the NIBC perioperative trest. #ESMO24 Tom Powles did it again!!! Another practice changing trial in the back OncoAlert ESMO - Eur. Oncology

NIAGARA is the first randomized trial to demonstrate significant OS difference in the NIBC perioperative trest. #ESMO24 
<a href="/tompowles1/">Tom Powles</a> did it again!!! Another practice changing trial in the back
<a href="/OncoAlert/">OncoAlert</a> <a href="/myESMO/">ESMO - Eur. Oncology</a>
Mirrors of Medicine (@mirrorsmed) 's Twitter Profile Photo

Fantastic talks on practical surgical questions on DAY 2 of #BLADDR24 - Practical aspects of intravesical instillation by Fred Witjes - The optimal TURBT by Ben-Max de Ruiter - The impact of RC on sexual function/experience by Pignot Géraldine Moderation: Cédric Lebâcle OncoAlert

Fantastic talks on practical surgical questions on DAY 2 of #BLADDR24 
- Practical aspects of intravesical instillation by Fred Witjes
- The optimal TURBT by Ben-Max de Ruiter
- The impact of RC on sexual function/experience by <a href="/PignotG/">Pignot Géraldine</a> 

Moderation: <a href="/CLebacle/">Cédric Lebâcle</a> 

<a href="/OncoAlert/">OncoAlert</a>
Toni Choueiri, MD (@drchoueiri) 's Twitter Profile Photo

JUST IN: U.S. FDA expands Lu-PSMA metastatic castration-resistant prostate cancer indication: now in Taxane-Naive population. Approval based on PSMAfore trial open Dana-Farber Lank Center for Genitourinary Oncology -rPFS 9.3 vs. 5.6mos (HR: 0.41) -OS HR 0.91 Through ASCO FDA alerts.

JUST IN: <a href="/US_FDA/">U.S. FDA</a>  expands Lu-PSMA metastatic castration-resistant prostate cancer indication: now in Taxane-Naive population. Approval based on PSMAfore trial open <a href="/DanaFarber_GU/">Dana-Farber Lank Center for Genitourinary Oncology</a> 

-rPFS 9.3 vs. 5.6mos (HR: 0.41)
-OS HR 0.91

Through <a href="/ASCO/">ASCO</a> FDA alerts.
Tom Powles (@tompowles1) 's Twitter Profile Photo

The FDA approved perioperative duvalumab with neoadjuvant chemo for muscle invasive bladder cancer today. It’s the only perioperative immune therapy trial with significant OS (0.75). Surgical safety was maintained. NCCN approval recently too #GUtrends25 fda.gov/drugs/resource…

Laura Bukavina (@laurabukavinamd) 's Twitter Profile Photo

TAR-200 in BCG-unresponsive NMIBC #AUA25 •82% CR rate at anytime •53% ≥12-mo durability CR •86.6% cystectomy-free at 12 mo If you compare to other available tx➡️➡️At 12 mo duration ‼️TAR-200 53% ≥12-mo DOR vs Adstiladrin 46%, Anktiva+BCG 58%

TAR-200 in BCG-unresponsive NMIBC #AUA25
•82% CR rate at anytime 
•53% ≥12-mo durability CR
•86.6% cystectomy-free at 12 mo
If you compare to other available tx➡️➡️At 12 mo duration 
‼️TAR-200 53% ≥12-mo DOR vs Adstiladrin 46%, Anktiva+BCG 58%
Félix Guerrero-Ramos (@drfelixguerrero) 's Twitter Profile Photo

🤩Privileged to be co-author in this paper on the CREST trial published at Nature Medicine with Tom Powles Matt Galsky Joan Palou Redorta Evanguelos Xylinas Alberto Briganti among others 🙌🏼Thrilled to be part of an eventual paradigm shift in #NMIBC after 50 years 👣This is only the

🤩Privileged to be co-author in this paper on the CREST trial published at <a href="/NatureMedicine/">Nature Medicine</a> with <a href="/tompowles1/">Tom Powles</a> <a href="/MattGalsky/">Matt Galsky</a> <a href="/joanfundi/">Joan Palou Redorta</a> <a href="/evanguelosx/">Evanguelos Xylinas</a> <a href="/Albert0Briganti/">Alberto Briganti</a> among others

🙌🏼Thrilled to be part of an eventual paradigm shift in #NMIBC after 50 years

👣This is only the
EAU YAU Urothelial Carcinoma (@eau_yaurotheli) 's Twitter Profile Photo

Our team is in Sevilla for #UROonco25 📩 #NMIBC Deintensify LG Biomarkers to ⬇️ cystoscopy in HG #MIBC ctDNA is the future #UTUC Tailored patient care Go for kidney-sparing treatment European Association of Urology (EAU) EAU Edu Platform UROONCO EAU Young Academics

Our team is in Sevilla for #UROonco25 

📩

#NMIBC 
Deintensify LG
Biomarkers to ⬇️ cystoscopy in HG

#MIBC 
ctDNA is the future

#UTUC 
Tailored patient care
Go for kidney-sparing treatment 

<a href="/Uroweb/">European Association of Urology (EAU)</a> <a href="/EAU_Uroonco/">EAU Edu Platform UROONCO</a> <a href="/EAUYAUrology/">EAU Young Academics</a>