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I have 2 posts on cancer immuno-epigenetics available in my lab: if you are passionate about understanding and combating tumour immune evasion, this could be for you! Dark antigens, interferon responses, chromatin regulators, hush, zfps….and more!

Happy to present our work at #ICTE2024. Congratulations Ana Ariza-Cosano! A pity I couldn't be there..

Together with Cedric🧬➰🧬Feschotte talk, this beautiful talk by Ana Ariza Cosano is making a very compelling case for the very important role of endogenous retroviruses in early development in zebrafish #ICTE2024

Really cool talk by Ana-Arista Cosano on yet another endogenous retrovirus required for zebrafish development! Transposon addiction again? #icte2024

🔴 Our new preprint up on bioRxiv Molecular Biology. Our results suggest that heterozygous DGCR8 phenotype is highly primate-specific (ps), affecting to ps-microRNA clusters and human endogenous retrovirus H (HERVH). Sara R Heras Sara Macias biorxiv.org/content/10.110…

This result tries to clarify the contribution of DGCR8 to 22q11 deletion syndrome, showing that human/primate models are needed to understand better this syndrome.

This work highlights the potential co-evolution of miRNAs and Transposable Elements to orchestrate crucial steps in early development in primates.

Really excited to share our last work in collaboration with Sara Macias: "DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects"! biorxiv.org/content/10.110…

Delighted to share this preprint that has taken a lot of hard work, especially from Amador Gallardo who has led the finding of a surprising alternative function of BMAL1 as a regulator of MERVL TEs in pluripotent cells. biorxiv.org/content/10.110…

🔴🔴🔴 ¡ESTO ES FLIPANTE! 😍😍😍 Nature ha seleccionado las 25 lecturas más interesantes de los últimos 40 años sobre los microARN (excluyendo Nobeles) y ¡está nuestro artículo en Nature Communications! ➡️ nature.com/collections/ea… Enhorabuena a Pablo Tristán Ramos y a nuestra IP, Sara R Heras.

El Nobel de Medicina 2024 ha sido para los descubridores de los microRNAS. La revista Nature ha seleccionado nuestro artículo de 2020 como una de las investigaciones más relevantes sobre este tema 😯

The 2024 Nobel Prize in Physiology or Medicine has been awarded jointly to Victor Ambros and Gary Ruvkun "for the discovery of microRNA and its role in post-transcriptional gene regulation.” Nature Portfolio presents this Collection to celebrate the award. go.nature.com/4eA5Nq2

#FFarmaciaUGR La Profesora de la Facultad, Sara R. Heras Sara R Heras, Dpto BBM2, figura en la recopilación Nature Portfolio de los artículos más relevantes publicados en las últimas 2 décadas relacionados con microRNAs. ¡ENHORABUENA! 👏👏 Vía Universidad Granada canal.ugr.es/noticia/nature…

Hoy el Día Internacional del Síndrome 22q nos pilla divididos entre: 🇪🇸 Granada 🇬🇧 Leicester 🇩🇰 Århus Pero no nos olvidamos de visibilizarlo ❤️ #hazvisible22q #iluminatepor22q

Esta pérdida de un alelo de DGCR8 ocurre en el síndrome 22q11 y señala que no siempre los modelos de ratón reflejan la complejidad en humana. Gracias a los coautores y las IPs Sara R Heras y Sara Macias. Artículo aquí ➡️ academic.oup.com/nar/article/53…

This effect is highly relevant in 22q11.2 deletion syndrome and shows striking differences between human and mouse models. Thanks to all coauthors and specially PIs Sara R Heras Sara Macias. Read the paper! ➡️ academic.oup.com/nar/article/53…